Issue 13, 2019
From the journal:

CrystEngComm

Co-crystallization and polymorphic behaviour of 5-fluorouracil†

Dennis D. Enkelmann,a   Jens Handelmann,b   Carsten Schauertec  and  Klaus Merz ORCID logo *b  

* Corresponding authors

a Institute of Pharmacy, University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria

b Inorganic Chemistry I – Bioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44797 Bochum, Germany
E-mail: Klaus.merz@rub.de

c Solid-Chem GmbH, Universitätstrasse 136, 44799 Bochum, Germany

Abstract

Syntheses and single-crystal characterization of two co-crystalline 5-fluorouracil compounds with nontoxic co-formers of the GRAS list, succinic acid and adipic acid, are presented. Furthermore, the target-oriented synthon approach from methanol or ethanol (technical grade) to polymorphic form II, which is hitherto only accessible from dry nitromethane, is described.

Graphical abstract: Co-crystallization and polymorphic behaviour of 5-fluorouracil

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Article information

DOI
https://doi.org/10.1039/C8CE01692E
Article type
Paper
Submitted
05 10 2018
Accepted
12 11 2018
First published
13 11 2018

CrystEngComm, 2019,21, 2130-2134

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Co-crystallization and polymorphic behaviour of 5-fluorouracil

D. D. Enkelmann, J. Handelmann, C. Schauerte and K. Merz, CrystEngComm, 2019, 21, 2130 DOI: 10.1039/C8CE01692E

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