Themed collection Biomaterials Science Recent Review Articles, 2024
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Wireless control of nerve growth using bipolar electrodes: a new paradigm in electrostimulation
Wired electrodes for nervous system stimulation have inherent limitations. Electrostimulation using unwired bipolar electrodes offers a new paradigm to drive growth and repair of nervous tissue. It also opens a wide field for innovation of electrode materials and protocols.
Biomater. Sci., 2024,12, 2180-2202
https://doi.org/10.1039/D3BM01946B
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Molecular basis for non-invasive diagnostics of cardiac amyloids using bone tracers
Cardiac deposition of amyloid transthyretin (ATTR) can be lethal. Radioactive bone tracers like Tc-labeled diphosphonates (yellow) are taken up by ATTR fibrils (gray). Acidic residue arrays (red) can bind calcium (blue) that can bind tracers.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D4BM00816B
Telomerase: a nexus between cancer nanotherapy and circadian rhythm
The use of nanoparticles for identifying and suppressing telomerase presents promising opportunities for anticancer strategies, particularly in relation to circadian regulation.
Biomater. Sci., 2024,12, 2259-2281
https://doi.org/10.1039/D4BM00024B
Liquid–liquid phase separation-inspired design of biomaterials
Biological liquid–liquid phase separation (LLPS) provides novel insights for the assembly of biomaterials with tailored structure and intrinsic functionality.
Biomater. Sci., 2024,12, 1943-1949
https://doi.org/10.1039/D3BM02008H
Natural products applied in acute kidney injury treatment: polymer matters
The applications of renal-targeting natural polymers and polymer-delivered natural drugs for the treatment of lethal acute kidney injury are summarized.
Biomater. Sci., 2024,12, 621-633
https://doi.org/10.1039/D3BM01772A
Recent advances in composite hydrogels: synthesis, classification, and application in the treatment of bone defects
Bone defects are often difficult to treat due to their complexity and specificity, and therefore pose a serious threat to human life and health.
Biomater. Sci., 2024,12, 308-329
https://doi.org/10.1039/D3BM01795H
Single atom nanozymes for bacterial infection therapy
Bacterial infection-related diseases continue to pose a significant challenge to global human health. Single-atom nanozymes (SAzymes) have shown promissing potential as novel antibacterial agents for the future.
Biomater. Sci., 2024,12, 108-115
https://doi.org/10.1039/D3BM01838E
Graphene-based metal/metal oxide nanocomposites as potential antibacterial agents: a mini-review
The possible antimicrobial mechanism of nanomaterials.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D4BM00796D
Recent advances in near-infrared stimulated nanohybrid hydrogels for cancer photothermal therapy
Photothermal nanogels exhibit good colloidal stability and high drug loading capacity, and can selectively accumulate at the tumor site through active or passive targeting, and then synergize with photothermal therapy to kill the tumor.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D4BM00662C
Advances in Microneedles Technology for Biomedical detection
Biomater. Sci., 2024, Accepted Manuscript
https://doi.org/10.1039/D4BM00794H
Nanomedicine for combination of chemodynamic therapy and immunotherapy of cancers
The combination of chemodynamic therapy (CDT) with immunotherapy can result in enhanced therapeutic effects of cancers. The recent progresses and challenges concerning nanomedicine for combination of CDT and immunotherapy are summarized and discussed.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D3BM02133E
Peptide-based supramolecular hydrogels and their biotherapeutic applications
Biomater. Sci., 2024, Accepted Manuscript
https://doi.org/10.1039/D4BM00865K
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Tailoring of bioactive glass and glass-ceramics properties for in vitro and in vivo response optimization: a review
Ion doping, drug loading, functionalization, coating and topographical modification allow to tailor the properties of bioactive glass and glass-ceramics and modulate the interaction of these bioceramics with human and bacterial cells.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D3BM01574B
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Lanthanide-doped upconversion nanoparticles as nanoprobes for bioimaging
Biomater. Sci., 2024, Accepted Manuscript
https://doi.org/10.1039/D4BM00774C
Medical and molecular biophysical techniques as substantial tools in the era of mRNA-based vaccine technology
Biophysical techniques involved in the formulation of mRNA products.
Biomater. Sci., 2024,12, 4117-4135
https://doi.org/10.1039/D4BM00561A
Splittable systems in biomedical applications
Splittable systems divide active molecules into inactive parts that recombine under specific conditions for versatile biomedical uses. Applications include immunotherapy, gene editing, prodrug activation, synthetic biology, and biosensing.
Biomater. Sci., 2024,12, 4103-4116
https://doi.org/10.1039/D4BM00709C
Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications
Hydrogen peroxide (H2O2) as a reactive oxygen species produced by cellular metabolism can be used in antitumor therapy.
Biomater. Sci., 2024,12, 4083-4102
https://doi.org/10.1039/D4BM00366G
Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment
The innovative and efficacious application of nanotechnology for remodeling the glioblastoma (GBM) tumor microenvironment (TME) exhibits promising potential as a therapeutic avenue for GBM treatment.
Biomater. Sci., 2024,12, 4045-4064
https://doi.org/10.1039/D4BM00665H
Bibliometric and visualization analysis of the application of inorganic nanomaterials to autoimmune diseases
Bibliometric analysis of the application of inorganic nanomaterials to autoimmune diseases is used to characterize current research trends and to visualize past and emerging trends in this field in the past 15 years.
Biomater. Sci., 2024,12, 3981-4005
https://doi.org/10.1039/D3BM02015K
Biomaterials as a new option for treating sensorineural hearing loss
Biomaterials as a new option has revolutionized the treatment of sensorineural hearing loss.
Biomater. Sci., 2024,12, 4006-4023
https://doi.org/10.1039/D4BM00518J
Hydrogen therapy: recent advances and emerging materials
Traditional methods of hydrogen administration are less efficient; novel photocatalytic and sonocatalytic materials with targeted delivery and stimuli-reactive hydrogen release can improve the therapeutic effect.
Biomater. Sci., 2024,12, 4136-4154
https://doi.org/10.1039/D4BM00446A
Towards the development of sensation-enabled skin substitutes
Innervation is a critical step in functional skin repair. Current study highlights the regenerative approaches to restore skin sensation after trauma.
Biomater. Sci., 2024,12, 4024-4044
https://doi.org/10.1039/D4BM00576G
Nanozymes in Alzheimer's disease diagnostics and therapy
The principle and application of nanozymes in the early diagnosis and treatment of Alzheimer's disease.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D4BM00586D
Design considerations and biomaterials selection in embedded extrusion 3D bioprinting
In embedded extrusion 3D bioprinting, a temporary matrix preserves a paste-like filament ejecting from a narrow nozzle.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D4BM00550C
Reactive oxygen species driven prodrug-based nanoscale carriers for transformative therapies
Reactive oxygen species (ROS) play a dual role in pathology and therapy. ROS-responsive nanoscale drug carriers offer a promising strategy to leverage elevated ROS levels in diseased tissues for targeted, enhanced therapeutic delivery and efficacy.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D4BM00647J
3D-printed microrobots for biomedical applications
The 3D printing technologies, structures and materials suitable for microrobots are elaborately discussed. The current progress, challenges and potential solutions of 3D printing microrobots in biomedical applications are discussed.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D4BM00674G
Stimuli-responsive polymer-based nanosystems for cardiovascular disease theranostics
Stimuli-responsive polymer-based nanosystems have gained significant attention for cardiovascular disease theranostics. This review summarizes various stimuli-responsive nanosystems used for diagnosing and treating cardiovascular diseases.
Biomater. Sci., 2024,12, 3805-3825
https://doi.org/10.1039/D4BM00415A
Self-assembled methodologies for the construction of DNA nanostructures and biological applications
Overview of the methodologies and applications of DNA self-assembly, including the conventional strategy based on Watson–Crick base-pairing, hybrid assembly mediated by functional elements and their applications in biological fields.
Biomater. Sci., 2024,12, 3712-3724
https://doi.org/10.1039/D4BM00584H
A comprehensive exploration of hydrogel applications in multi-stage skin wound healing
Hydrogels, as an emerging biomaterial, have found extensive use in the healing of wounds due to their distinctive physicochemical structure and functional properties.
Biomater. Sci., 2024,12, 3745-3764
https://doi.org/10.1039/D4BM00394B
Fluorescence imaging-guided surgery: current status and future directions
Illustrative representation of applications of fluorescence imaging-guided surgery in different types of cancers by utilizing different fluorescent probes.
Biomater. Sci., 2024,12, 3765-3804
https://doi.org/10.1039/D4BM00410H
Prospects, advances and biological applications of MOF-based platform for the treatment of lung cancer
Herein, we reviewed the recent development in the use of MOF materials as a platform for the treatment of lung cancer.
Biomater. Sci., 2024,12, 3725-3744
https://doi.org/10.1039/D4BM00488D
Functional structures assembled based on Au clusters with practical applications
Assembled structures of Au NCs in combination with different metal agents are intricately arranged through chemical forces, it resulted a diverse array of multifunctional Au NCs assemblies and being utilized in different biological applications.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D4BM00455H
Navigating the challenges and exploring the perspectives associated with emerging novel biomaterials
The field of biomaterials is a continuously evolving interdisciplinary field encompassing biological sciences, materials sciences, chemical sciences, and physical sciences with a multitude of applications realized every year.
Biomater. Sci., 2024,12, 3565-3581
https://doi.org/10.1039/D4BM00376D
A comprehensive review of engineered exosomes from the preparation strategy to therapeutic applications
This review systematically summarizes the cutting-edge methods for preparing engineered exosomes through cell engineering and exosome engineering, as well as the latest advancements of engineered exosomes in therapeutic applications.
Biomater. Sci., 2024,12, 3500-3521
https://doi.org/10.1039/D4BM00558A
Advances in 3D tissue models for neural engineering: self-assembled versus engineered tissue models
Self-assembled models offer advantages in studying neural development, but standardisation, control, and scalability are limited. Engineering hydrogel-based models to mimic native tissue structures shows promise in overcoming these challenges.
Biomater. Sci., 2024,12, 3522-3549
https://doi.org/10.1039/D4BM00317A
Functionalized extracellular nanovesicles as advanced CRISPR delivery systems
This review highlights the advances of functional extracellular nanovesicles in CRISPR delivery, including their cellular entry pathways, functionalization techniques, and the challenges and strategies pivotal for clinical translation.
Biomater. Sci., 2024,12, 3480-3499
https://doi.org/10.1039/D4BM00054D
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Artificial keloid skin models: understanding the pathophysiological mechanisms and application in therapeutic studies
Keloid is a type of scar formed by the overexpression of extracellular matrix substances from fibroblasts following inflammation after trauma.
Biomater. Sci., 2024,12, 3321-3334
https://doi.org/10.1039/D4BM00005F
Gases and gas-releasing materials for the treatment of chronic diabetic wounds
This article reviews the latest progress in the mechanism and treatment of different gases and related gas releasing materials in diabetic wound repair.
Biomater. Sci., 2024,12, 3273-3292
https://doi.org/10.1039/D4BM00351A
4D hydrogels: fabrication strategies, stimulation mechanisms, and biomedical applications
4D hydrogels mimic anisotropic tissue composition due to non-uniform distribution of internal stresses within them. Herein, we discuss the strategies used to fabricate programmable hydrogels in response to environmental cues for biomedical applications.
Biomater. Sci., 2024,12, 3249-3272
https://doi.org/10.1039/D3BM02044D
Antibacterial polylysine-containing hydrogels for hemostatic and wound healing applications: preparation methods, current advances and future perspectives
Polylysine, renowned for its outstanding antibacterial efficacy, has shown significant promise in the biomedical field. This review presents various preparation methods and recent advances in polylysine-containing hydrogels to promote wound healing.
Biomater. Sci., 2024,12, 3293-3320
https://doi.org/10.1039/D3BM01792C
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Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is pivotal in orchestrating the immune response induced by most of the nanoparticle adjuvants.
Biomater. Sci., 2024, Advance Article
https://doi.org/10.1039/D4BM00439F
Non-viral vector-based genome editing for cancer immunotherapy
Non-viral vector-based CRISPR-Cas-mediated immunoengineering in tumor cells and immune cells for cancer immunotherapy.
Biomater. Sci., 2024,12, 3068-3085
https://doi.org/10.1039/D4BM00286E
Advances in non-viral mRNA delivery to the spleen
Developing safe and effective delivery strategies for localizing messenger RNA (mRNA) payloads to the spleen is an important goal in the field of genetic medicine.
Biomater. Sci., 2024,12, 3027-3044
https://doi.org/10.1039/D4BM00038B
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Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting
GI transporter/receptor-mediated nanosized drug delivery systems could improve oral absorption and further target organs or diseases for effective therapeutic outcomes.
Biomater. Sci., 2024,12, 3045-3067
https://doi.org/10.1039/D4BM00313F
Protein–polymer bioconjugation, immobilization, and encapsulation: a comparative review towards applicability, functionality, activity, and stability
Protein–polymer bioconjugation, immobilization, and encapsulation exhibit a unique array of properties and can be tuned to produce desired effects for specific biomaterial applications.
Biomater. Sci., 2024,12, 2841-2864
https://doi.org/10.1039/D3BM01861J
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Porphyrin-based covalent organic frameworks from design, synthesis to biological applications
Covalent organic frameworks (COFs) constitute a class of highly functional porous materials composed of lightweight elements interconnected by covalent bonds, characterized by structural order, high crystallinity, and large specific surface area.
Biomater. Sci., 2024,12, 2766-2785
https://doi.org/10.1039/D4BM00214H
Cell-membrane engineering strategies for clinic-guided design of nanomedicine
In this review, four types of cell membrane functionalities and applications are summarized, which elucidate their working principles, outline the current approaches for engineering cell membranes, and discuss their potential clinical applications.
Biomater. Sci., 2024,12, 2865-2884
https://doi.org/10.1039/D3BM02114A
A type I and type II chemical biology toolbox to overcome the hypoxic tumour microenvironment for photodynamic therapy
A chemicobiology toolbox for type I and type II photodynamic therapy.
Biomater. Sci., 2024,12, 2831-2840
https://doi.org/10.1039/D4BM00319E
Advances in conductive hydrogels for neural recording and stimulation
Brain-computer interface (BCI) allows the human or animal brain to directly interact with the external environment through the neural interfaces, thus playing the role of monitoring, protecting, improving/restoring, enhancing, and replacing the human brain or body.
Biomater. Sci., 2024,12, 2786-2800
https://doi.org/10.1039/D4BM00048J
Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering
The current efforts to ameliorate the coupling of osteogenesis and angiogenesis were summarized comprehensively and explored in depth from the optimization strategies of scaffolds to the employment tricks for bioactive substances and cells.
Biomater. Sci., 2024,12, 2801-2830
https://doi.org/10.1039/D3BM02017G
Photothermal therapy: a novel potential treatment for prostate cancer
This review discussed photothermal therapy from basic information to its circumstances and potential in protate cancer treatment.
Biomater. Sci., 2024,12, 2480-2503
https://doi.org/10.1039/D4BM00057A
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Multifunctional antibacterial hydrogels for chronic wound management
Due to their distinctive physical and chemical properties as well as their biological functionalities, multifunctional antibacterial hydrogels possess significant advantages in the treatment of chronic wounds.
Biomater. Sci., 2024,12, 2460-2479
https://doi.org/10.1039/D4BM00155A
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The unexplored role of alkali and alkaline earth elements (ALAEs) on the structure, processing, and biological effects of bioactive glasses
Alkali and alkaline earth elements play a crucial role in the structure, processing, and properties of bioactive glasses, widely used in medical applications since their inception in 1969.
Biomater. Sci., 2024,12, 2521-2560
https://doi.org/10.1039/D3BM01338C
Janus hydrogels: merging boundaries in tissue engineering for enhanced biomaterials and regenerative therapies
In recent years, the design and synthesis of Janus hydrogels have advanced significantly, overcoming single-performance material limitations and broadening applications in tissue engineering and regenerative medicine.
Biomater. Sci., 2024,12, 2504-2520
https://doi.org/10.1039/D3BM01875J
Exosomes encapsulated in hydrogels for effective central nervous system drug delivery
The targeted delivery of pharmacologically active molecules, metabolites, and growth factors to the brain parenchyma has become one of the major challenges following the onset of neurodegeneration and pathological conditions.
Biomater. Sci., 2024,12, 2561-2578
https://doi.org/10.1039/D3BM01055D
Machine learning in nanozymes: from design to application
Nanozymes, a distinctive class of nanomaterials with enzyme-like activity and kinetics akin to enzyme-catalysed reactions, present several advantages over natural enzymes, including cost-effectiveness, heightened stability, and adjustable activity.
Biomater. Sci., 2024,12, 2229-2243
https://doi.org/10.1039/D4BM00169A
Engineering unactivated platelets for targeted drug delivery
Unactivated platelets could be constructed via external modification, internal loading, genetic engineering and cell conjugation, and applied as targeted drug delivery carriers for cardiovascular disease, cancer and pathogen infection therapy.
Biomater. Sci., 2024,12, 2244-2258
https://doi.org/10.1039/D4BM00029C
Emerging nanoparticle platforms for CpG oligonucleotide delivery
In this review, we provide a comprehensive summary of the nanoparticle-based CpG delivery systems developed to improve the efficacy of CpG-mediated immune responses.
Biomater. Sci., 2024,12, 2203-2228
https://doi.org/10.1039/D3BM01970E
Recent advances in shape memory polymeric nanocomposites for biomedical applications and beyond
Shape memory polymers (SMPs), which initiate shape transformation in response to environmental stimuli, have attracted significant attention in both academic research and technological innovation.
Biomater. Sci., 2024,12, 2033-2040
https://doi.org/10.1039/D4BM00004H
Nanotechnology-based delivery of therapeutics through the intranasal pathway and the blood–brain barrier for Alzheimer's disease treatment
Drugs for Alzheimer's disease (AD) fail to exhibit efficacy in clinical trials for a number of reasons, a major one being blood–brain barrier (BBB) permeability.
Biomater. Sci., 2024,12, 2007-2018
https://doi.org/10.1039/D3BM02003G
Recent progress in nanomaterials for bacteria-related tumor therapy
Recent progress in nanomaterials for bacteria-related tumor therapy in terms of chemotherapy, immunotherapy and synergistic therapy is summarized in this review in order to provide some insights into this emerging and rapidly growing research area.
Biomater. Sci., 2024,12, 1965-1980
https://doi.org/10.1039/D3BM01952G
Highly-ordered assembled organic fluorescent materials for high-resolution bio-sensing: a review
Organic fluorescent materials (OFMs) play a crucial role in the development of biosensors, enabling the extraction of biochemical information within cells and organisms, extending to the human body.
Biomater. Sci., 2024,12, 2019-2032
https://doi.org/10.1039/D3BM02070C
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Biomaterial engineering strategies for B cell immunity modulations
Biomaterials enhance B cell immunity by modulating the delivery approach, crosslinking B cell receptors, and promoting T cell help, while inhibitory co-receptor engagement via biomaterial design suppresses B cell function.
Biomater. Sci., 2024,12, 1981-2006
https://doi.org/10.1039/D3BM01841E
Microgels for bioprinting: recent advancements and challenges
This review introduces different methods used to generate microgels and the microgel-based bioink for bioprinting. Besides, the further tendency of microgel development in future is predicted.
Biomater. Sci., 2024,12, 1950-1964
https://doi.org/10.1039/D3BM01733H
Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers
Electrospun nanofibers with fascinating properties provide a versatile platform for postoperative tissue anti-adhesion.
Biomater. Sci., 2024,12, 1643-1661
https://doi.org/10.1039/D3BM02038J
Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer
Existing treatments could be sensitized by targeting the ferroptosis pathway in prostate cancer.
Biomater. Sci., 2024,12, 1617-1629
https://doi.org/10.1039/D3BM01894F
Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine
In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, the potential applications for cancer treatment and future development prospects are also prospected.
Biomater. Sci., 2024,12, 1662-1692
https://doi.org/10.1039/D3BM01451G
Applications of peptide-based nanomaterials in targeting cancer therapy
To meet the precise diagnosis and treatment as well as reduce systemic toxicity and side effects, self-assembled peptides are applied to the targeting therapy, including targeting theranostics, nanocarrier delivery, immunotherapy, and combination therapy.
Biomater. Sci., 2024,12, 1630-1642
https://doi.org/10.1039/D3BM02026F
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Applications, advancements, and challenges of 3D bioprinting in organ transplantation
To date, organ transplantation remains an effective method for treating end-stage diseases of various organs.
Biomater. Sci., 2024,12, 1425-1448
https://doi.org/10.1039/D3BM01934A
Blood–brain barrier-crossing dendrimers for glioma theranostics
Blood–brain barrier-crossing dendrimers for glioma imaging diagnostics, chemotherapy, gene therapy, or imaging-guided therapy have been concisely reviewed with perspectives briefly discussed.
Biomater. Sci., 2024,12, 1346-1356
https://doi.org/10.1039/D4BM00043A
About this collection
This collection contains recent Review-type articles published by Biomaterials Science. New articles will be added to this collection as soon as possible after publication.