Hinano Takemura, Gaku Orimoto, Akihiro Kobayashi, Takamitsu Hosoya and Suguru Yoshida
Org. Biomol. Chem., 2022,20, 6007-6011
DOI:
10.1039/D2OB00151A,
Paper
Assembling methods using 2-azidoacrylamides having a nucleophilic amino group are disclosed. Divergent transformations of the amine-type trivalent platform were accomplished with a wide variety of electrophiles to obtain a broad range of 2-azidoacrylamides involving a fluorosulfonyl group-containing trivalent platform. Consecutive click conjugations including triazole formation, thiol–ene-type 1,4-addition, and SuFEx reactions realized the efficient assembly of easily available simple modules.