Issue 10, 2016

Switching between intermolecular and intramolecular reactions using flow microreactors: lithiation of 2-bromo-2′-silylbiphenyls

Abstract

Reaction-pathway control of 2-lithio-2′-silylbiphenyls was accomplished in flow microreactor systems. Effective switching between the intermolecular reaction with an electrophile and the intramolecular reaction was performed at will by choosing an appropriate residence time and temperature region.

Graphical abstract: Switching between intermolecular and intramolecular reactions using flow microreactors: lithiation of 2-bromo-2′-silylbiphenyls

Supplementary files

Article information

Article type
Research Article
Submitted
09 Мау. 2016
Accepted
25 Шіл. 2016
First published
26 Шіл. 2016

Org. Chem. Front., 2016,3, 1250-1253

Switching between intermolecular and intramolecular reactions using flow microreactors: lithiation of 2-bromo-2′-silylbiphenyls

A. Nagaki, S. Kim, N. Miuchi, H. Yamashita, K. Hirose and J. Yoshida, Org. Chem. Front., 2016, 3, 1250 DOI: 10.1039/C6QO00257A

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