Switching between intermolecular and intramolecular reactions using flow microreactors: lithiation of 2-bromo-2′-silylbiphenyls

Abstract

Reaction-pathway control of 2-lithio-2′-silylbiphenyls was accomplished in flow microreactor systems. Effective switching between the intermolecular reaction with an electrophile and the intramolecular reaction was performed at will by choosing an appropriate residence time and temperature region.