Issue 10, 2012
From the journal:

Chemical Science

A nanocrystal-based ratiometric pH sensor for natural pH ranges†

Rebecca C. Somers,a   Ryan M. Lanning,b   Preston T. Snee,‡a   Andrew B. Greytak,§a   Rakesh K. Jain,b   Moungi G. Bawendi*a  and  Daniel G. Nocera*a  

* Corresponding authors

a Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA
E-mail: nocera@mit.edu, mgb@mit.edu

b Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA 02114, USA
E-mail: jain@steele.mgh.harvard.edu

Abstract

A ratiometric fluorescent pH sensor based on CdSe/CdZnS nanocrystal quantum dots (NCs) has been designed for biological pH ranges. The construct is formed from the conjugation of a pH dye (SNARF) to NCs coated with a poly(amido amine) (PAMAM) dendrimer. The sensor exhibits a well-resolved ratio response at pH values between 6 and 8 under linear or two-photon excitation, and in the presence of a 4% bovine serum albumin (BSA) solution.

Graphical abstract: A nanocrystal-based ratiometric pH sensor for natural pH ranges

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2SC20212C
Article type
Edge Article
Submitted
21 Ақп. 2012
Accepted
22 Мау. 2012
First published
26 Мау. 2012

Chem. Sci., 2012,3, 2980-2985

Permissions

Request permissions

A nanocrystal-based ratiometric pH sensor for natural pH ranges

R. C. Somers, R. M. Lanning, P. T. Snee, A. B. Greytak, R. K. Jain, M. G. Bawendi and D. G. Nocera, Chem. Sci., 2012, 3, 2980 DOI: 10.1039/C2SC20212C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements