Themed collection Biocatalysis: A cross-journal collection

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Perspective

Status check: biocatalysis; its use with and without chemocatalysis. How does the fine chemicals industry view this area?

Stages of the penetration of catalytic technology and the necessity for fruitful collaboration.

Graphical abstract: Status check: biocatalysis; its use with and without chemocatalysis. How does the fine chemicals industry view this area?
From the themed collection: 2023 Green Chemistry Reviews
Perspective

Tuning properties of biocatalysis using protein cage architectures

The properties of biocatalysis can be tuned by encapsulation of enzymes inside protein cages, which alters enzyme behaviors, substrate access and product release, and efficiency of cascade reactions.

Graphical abstract: Tuning properties of biocatalysis using protein cage architectures
Open Access Perspective

Light-driven biocatalytic oxidation

Light-driven catalytic cycles by oxidative enzymes, such as peroxygenases, dehydrogenases or monooxygenases, perform a variety of selective oxyfunctionalization and dehydrogenation reactions with or withdrawal of reducing equivalents.

Graphical abstract: Light-driven biocatalytic oxidation
From the themed collection: Biocatalysis: A cross-journal collection
Perspective

Biocatalysis in ionic liquids: state-of-the-union

This perspective reviews the current status and prospects of biocatalysis in ionic liquids.

Graphical abstract: Biocatalysis in ionic liquids: state-of-the-union
From the themed collection: Biocatalysis: A cross-journal collection
Minireview

Development of a continuous-flow system with immobilized biocatalysts towards sustainable bioprocessing

Implementing immobilized biocatalysts in continuous-flow systems can enable a sustainable process through enhanced enzyme stability, better transport and process continuity as well as simplified recycle and downstream processing.

Graphical abstract: Development of a continuous-flow system with immobilized biocatalysts towards sustainable bioprocessing
From the themed collection: Biocatalysis: A cross-journal collection
Minireview

Biosynthesis of chiral cyclic and heterocyclic alcohols via C[double bond, length as m-dash]O/C–H/C–O asymmetric reactions

This review covers the recent progress in various biological approaches applied to the synthesis of enantiomerically pure cyclic and heterocyclic alcohols through C[double bond, length as m-dash]O/C–H/C–O asymmetric reactions.

Graphical abstract: Biosynthesis of chiral cyclic and heterocyclic alcohols via C [[double bond, length as m-dash]] O/C–H/C–O asymmetric reactions
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Feature Article

Immobilisation and flow chemistry: tools for implementing biocatalysis

The application of immobilised enzymes in flow allows for process intensification, reduced reactor volumes and improved safety.

Graphical abstract: Immobilisation and flow chemistry: tools for implementing biocatalysis
From the themed collection: Biocatalysis: A cross-journal collection
Review Article

Reactive oxygen nanobiocatalysts: activity-mechanism disclosures, catalytic center evolutions, and changing states

This review offers a comprehensive and timely summarization of the most recent breakthroughs and future trends in creating reactive oxygen nanobiocatalysts, which guides their broad applications in diverse biomedical and biological fields.

Graphical abstract: Reactive oxygen nanobiocatalysts: activity-mechanism disclosures, catalytic center evolutions, and changing states
From the themed collection: Biocatalysis: A cross-journal collection
Review Article

Nucleic acid-functionalized nanozymes and their applications

Nucleic acid-modified nanozymes provide hybrid nanostructures that act as sensors, effective catalysts and bioreactor systems, DNA switches and catalysts for nano-biomedical applications.

Graphical abstract: Nucleic acid-functionalized nanozymes and their applications
From the themed collection: Recent Review Articles
Open Access Review Article

Microbial electrosynthesis: carbonaceous electrode materials for CO2 conversion

Microbial electrosynthesis (MES) is a sustainable approach to producing fuels and value-added chemicals from anthropogenic carbon dioxide (CO2).

Graphical abstract: Microbial electrosynthesis: carbonaceous electrode materials for CO2 conversion
From the themed collection: Recent Review Articles
Open Access Review Article

Biocatalytic conversion of sunlight and carbon dioxide to solar fuels and chemicals

Interfacing photocatalysts with microbes to produce solar fuels and chemicals from carbon dioxide and sunlight.

Graphical abstract: Biocatalytic conversion of sunlight and carbon dioxide to solar fuels and chemicals
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Review Article

Biocatalysis making waves in organic chemistry

The many waves of biocatalysis have arisen to solve long-standing synthetic challenges. From industrially applied hydrolases to enzymes catalysing selective C–C-bond formation, biocatalysis enables new tools to access a plethora of compounds.

Graphical abstract: Biocatalysis making waves in organic chemistry
From the themed collection: Biocatalysis: A cross-journal collection
Review Article

Immobilized enzymes in inorganic hybrid nanoflowers for biocatalytic and biosensing applications

Immobilized enzymes in inorganic hybrid nanoflowers for biocatalytic and biosensing applications.

Graphical abstract: Immobilized enzymes in inorganic hybrid nanoflowers for biocatalytic and biosensing applications
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Review Article

The role of biocatalysis in the asymmetric synthesis of alkaloids – an update

This review article discusses developments in the chemo-enzymatic synthesis of alkaloids since 2013, showcasing how modern methods of organic synthesis and biocatalysis are combined to establish novel routes towards these important natural products.

Graphical abstract: The role of biocatalysis in the asymmetric synthesis of alkaloids – an update
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Review Article

Recent trends in biocatalysis

Technological developments enable the discovery of novel enzymes, the advancement of enzyme cascade designs and pathway engineering, moving biocatalysis into an era of technology integration, intelligent manufacturing and enzymatic total synthesis.

Graphical abstract: Recent trends in biocatalysis
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Review Article

Flow biocatalysis 101: design, development and applications

Flow biocatalysis: where to start? This tutorial review aims to guide and inspire new-comers to the field to boost the potential of flow biocatalysis.

Graphical abstract: Flow biocatalysis 101: design, development and applications
From the themed collection: Biocatalysis: A cross-journal collection
Review Article

Biocatalytic approaches for enantio and diastereoselective synthesis of chiral β-nitroalcohols

Chiral β-nitroalcohols are versatile synthetic intermediates for several pharmaceuticals, and bioactive molecules. This review describes the importance and various biocatalytic approaches for their enantio and diastereoselective synthesis.

Graphical abstract: Biocatalytic approaches for enantio and diastereoselective synthesis of chiral β-nitroalcohols
From the themed collection: Biocatalysis: A cross-journal collection
Tutorial Review

Nanobiocatalysis: a materials science road to biocatalysis

This tutorial review highlights the recent achievements made in the field of nanobiocatalysis with emphasis on nano-integrated biocatalysis and bio-inspired nanocatalysis.

Graphical abstract: Nanobiocatalysis: a materials science road to biocatalysis
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Tutorial Review

New frontiers in enzyme immobilisation: robust biocatalysts for a circular bio-based economy

This tutorial review focuses on recent advances in technologies for enzyme immobilisation, enabling their cost-effective use in the bio-based economy and continuous processing in general.

Graphical abstract: New frontiers in enzyme immobilisation: robust biocatalysts for a circular bio-based economy
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Tutorial Review

Applied biocatalysis beyond just buffers – from aqueous to unconventional media. Options and guidelines

It's not only lipases which can be applied in alternative solvent systems to meet industrial and environmental demands. At the hand of case studies and flowcharts this review quickly shows what solvent systems are viable.

Graphical abstract: Applied biocatalysis beyond just buffers – from aqueous to unconventional media. Options and guidelines
From the themed collection: Biocatalysis: A cross-journal collection
Critical Review

Recent advances in the sustainable production of α,ω-C6 bifunctional compounds enabled by chemo-/biocatalysts

We review the recent progress of synthesis routes for four α,ω-C6 bifunctional compounds (6-hydroxyhexanoic acid, 6-aminocaproic acid, 1,6-hexanediol and 1,6-hexanediamine), focusing on routes involving sustainable catalysts or renewable feedstocks.

Graphical abstract: Recent advances in the sustainable production of α,ω-C6 bifunctional compounds enabled by chemo-/biocatalysts
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Communication

Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase

Immobilised TsOYE on Celite carrier catalyses the bioreduction of activated alkenes in pure organic solvent, providing full conversion to (chiral) products.

Graphical abstract: Biocatalytic reduction of alkenes in micro-aqueous organic solvent catalysed by an immobilised ene reductase
From the themed collection: Biocatalysis: A cross-journal collection
Communication

Comparative S-adenosyl-L-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

Comparison of S-adenosyl-L-methionine (SAM) analogue generation by halide methyltransferase (HMT) and methionine adenosyltransferase (MAT) for methyltransferase catalysed alkylation.

Graphical abstract: Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation
From the themed collection: 2023 Pioneering Investigators
Communication

First and second sphere interactions accelerate non-native N-alkylation catalysis by the thermostable, methanol-tolerant B12-dependent enzyme MtaC

The corrinoid protein MtaC, which is natively involved in methyl transferase catalysis, catalyzes N-alkylation of aniline using ethyl diazoacetate.

Graphical abstract: First and second sphere interactions accelerate non-native N-alkylation catalysis by the thermostable, methanol-tolerant B12-dependent enzyme MtaC
From the themed collection: Biocatalysis: A cross-journal collection
Communication

A multienzyme biocatalytic cascade as a route towards the synthesis of α,ω-diamines from corresponding cycloalkanols

We report a multienzymatic cascade for the synthesis of 1,6-hexamethylenediamine (HMD) and related α,ω-diamines from corresponding cycloalkanols.

Graphical abstract: A multienzyme biocatalytic cascade as a route towards the synthesis of α,ω-diamines from corresponding cycloalkanols
From the themed collection: Biocatalysis: A cross-journal collection
Communication

Visible-light-driven production of fumarate from CO2 and pyruvate using a photocatalytic system with dual biocatalysts

The unsaturated dicarboxylate fumarate was produced from pyruvate and CO2 by applying malate dehydrogenase and fumarase as a catalyst for the visible-light driven regeneration of NADH for the first time.

Graphical abstract: Visible-light-driven production of fumarate from CO2 and pyruvate using a photocatalytic system with dual biocatalysts
From the themed collection: Biocatalysis: A cross-journal collection
Communication

Catecholase-catalyzed synthesis of wedelolactone, a natural coumestan and its analogs

A green approach, catalyzed by the catecholase enzyme obtained from sweet potato, to generate bioactive wedelolactone and many of its analogs which are useful precursors for a variety of coumestan-based natural products.

Graphical abstract: Catecholase-catalyzed synthesis of wedelolactone, a natural coumestan and its analogs
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Communication

Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

Selective O-demethylation of the lignin monoaromatics, syringol and guaiacol, using the peroxygenase activity of two distinct cytochrome P450 enzymes.

Graphical abstract: Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Communication

Polymer-induced biofilms for enhanced biocatalysis

Here, we show how synthetic polymers, prepared by a combination of controlled radical polymerization and in-situ screening, can be used to address a biological challenge – how to improve biofilm formation – to provide solutions to a field – biocatalysis – of industrial and societal relevance.

Graphical abstract: Polymer-induced biofilms for enhanced biocatalysis
From the themed collection: Biocatalysis: A cross-journal collection
Communication

Biocatalytic fumarate synthesis from pyruvate and CO2 as a feedstock

The biocatalytic synthesis of fumarate from CO2 and pyruvate viaL-malate as an intermediate in an aqueous medium using a biocatalytic system consisting of malate dehydrogenase and fumarase in the presence of NADH is developed.

Graphical abstract: Biocatalytic fumarate synthesis from pyruvate and CO2 as a feedstock
From the themed collection: Biocatalysis & Bioprocessing
Open Access Communication

A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H

Soluble hydrogenase enables atom efficient, H2-driven, recycling of synthetic nicotinamide cofactors.

Graphical abstract: A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H
From the themed collection: Biocatalysis: A cross-journal collection
Communication

Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem

A ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution strategy was developed for the highly stereoselective and green synthesis of anti-aryl α-chloro β-hydroxy esters.

Graphical abstract: Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem
From the themed collection: Biocatalysis: A cross-journal collection
Communication

Biocatalytic CO2 fixation initiates selective oxidative cracking of 1-naphthol under ambient conditions

CO2 fixation initiates cracking: the enzymatic ortho-carboxylation activates the singly hydroxylated aromatic ring of naphthalene for the following selective cracking catalyzed by dioxygenase in a cofactor-free one-pot cascade reaction.

Graphical abstract: Biocatalytic CO2 fixation initiates selective oxidative cracking of 1-naphthol under ambient conditions
From the themed collection: Biocatalysis: A cross-journal collection
Communication

A light-controlled biocatalytic system for precise regulation of enzymatic decarboxylation

A light-controlled biocatalytic one-pot system is developed, which enables precise regulation of gene expression and photocatalysis by illumination and yields high conversion and stereoselectivity.

Graphical abstract: A light-controlled biocatalytic system for precise regulation of enzymatic decarboxylation
From the themed collection: Biocatalysis: A cross-journal collection
Communication

Multiple electron transfer pathways of tungsten-containing formate dehydrogenase in direct electron transfer-type bioelectrocatalysis

Multiple direct electron transfer pathways are discovered in Tungsten-containing formate dehydrogenase from the viewpoints of structural biology and bioelectrochemistry.

Graphical abstract: Multiple electron transfer pathways of tungsten-containing formate dehydrogenase in direct electron transfer-type bioelectrocatalysis
From the themed collection: Biocatalysis: A cross-journal collection
Communication

Constructing a multienzyme cascade redox-neutral system for the synthesis of halogenated indoles

A novel multienzyme cascade redox-neutral system for the synthesis of halogenated indoles from amino alcohols.

Graphical abstract: Constructing a multienzyme cascade redox-neutral system for the synthesis of halogenated indoles
From the themed collection: Biocatalysis: A cross-journal collection
Communication

One-pot biocatalytic synthesis of nylon monomers from cyclohexanol using Escherichia coli-based concurrent cascade consortia

We developed a multienzyme biocatalytic cascade with high atom efficiency and a self-sufficient redox network for the synthesis of nylon monomers without adding auxiliary enzymes to recycle cofactors.

Graphical abstract: One-pot biocatalytic synthesis of nylon monomers from cyclohexanol using Escherichia coli-based concurrent cascade consortia
From the themed collection: Biocatalysis: A cross-journal collection
Communication

Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

Bio-catalytic reactions involving ene-reductases (EREDs) in tandem with chemo-catalysis in water can be greatly enhanced by the presence of nanomicelles derived from the surfactant TPGS-750-M.

Graphical abstract: Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Communication

Improved biocatalytic cascade conversion of CO2 to methanol by enzymes Co-immobilized in tailored siliceous mesostructured cellular foams

CO2 can be enzymatically reduced to methanol in a cascade reaction involving three enzymes: formate-, formaldehyde- and alcohol dehydrogenase (FateDH, FaldDH, ADH).

Graphical abstract: Improved biocatalytic cascade conversion of CO2 to methanol by enzymes Co-immobilized in tailored siliceous mesostructured cellular foams
From the themed collection: Biocatalysis: A cross-journal collection
Communication

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Sulfoxides have been synthesised from various sulfide substrates under mild conditions exploiting CALB biocatalyst in the presence of urea hydrogen peroxide and AcOEt which acts with the dual role of solvent and reagent.

Graphical abstract: A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Edge Article

Concise synthesis of (R)-reticuline and (+)-salutaridine by combining early-stage organic synthesis and late-stage biocatalysis

Designing an alternative access to the morphinan scaffold by taking advantage of biocatalysis for asymmetric C[double bond, length as m-dash]N reduction and oxidative C–C bond formation.

Graphical abstract: Concise synthesis of (R)-reticuline and (+)-salutaridine by combining early-stage organic synthesis and late-stage biocatalysis
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Edge Article

Biocatalytic cascades and intercommunicated biocatalytic cascades in microcapsule systems

Dynamic dimerization of GOx-loaded microcapsules with β-gal//hemin/G-quadruplex-bridged T1/T2-loaded microcapsules guides the bi-directional intercommunication of the three catalysts cascade.

Graphical abstract: Biocatalytic cascades and intercommunicated biocatalytic cascades in microcapsule systems
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Edge Article

CO2-responsive Pickering emulsions stabilized by soft protein particles for interfacial biocatalysis

An unprecedented strategy was proposed for recycled interfacial biocatalysis in a CO2-responsive emulsion stabilized by soft protein particles. The recycled enzyme maintained its catalytic activity, with a conversion yield over 90% after 30 cycles.

Graphical abstract: CO2-responsive Pickering emulsions stabilized by soft protein particles for interfacial biocatalysis
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Edge Article

Engineering proteinaceous colloidosomes as enzyme carriers for efficient and recyclable Pickering interfacial biocatalysis

Engineering proteinaceous colloidosomes with magnetic-responsiveness are designed as both enzyme carrier and emulsifier, achieving a breakthrough in protein-based w/o Pickering interfacial biocatalysis.

Graphical abstract: Engineering proteinaceous colloidosomes as enzyme carriers for efficient and recyclable Pickering interfacial biocatalysis
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Edge Article

A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF, fluprostenol, and travoprost guided by biocatalytic retrosynthesis

We report a unified chemoenzymatic asymmetric synthesis of five prostaglandins, featuring two enzymatic redox transformations and a copper(II)-catalyzed regioselective p-phenylbenzoylation.

Graphical abstract: A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF2α, fluprostenol, and travoprost guided by biocatalytic retrosynthesis
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Enzyme-modified amphiphilic polymer nanoparticles as high-performance Pickering interface biocatalysts

Enzyme-decorated polymeric nanoparticles as both catalytic sites and stabilizers for a high catalytic activity and easily recyclable Pickering interface biocatalysis system.

Graphical abstract: Enzyme-modified amphiphilic polymer nanoparticles as high-performance Pickering interface biocatalysts
From the themed collection: Biocatalysis & Bioprocessing
Paper

Computational thermostability engineering of a nitrile hydratase using synergetic energy and correlated configuration for redesigning enzymes (SECURE) strategy

A computational strategy using synergetic energy and correlated configuration for redesigning enzymes (SECURE) is proposed for the thermostability engineering of multimeric proteins.

Graphical abstract: Computational thermostability engineering of a nitrile hydratase using synergetic energy and correlated configuration for redesigning enzymes (SECURE) strategy
Open Access Paper

FTIR microscopy for direct observation of conformational changes on immobilized ω-transaminase: effect of water activity and organic solvent on biocatalyst performance

Enzyme immobilization is a key strategy to expand the scope of enzyme applications and to enable the recycling of biocatalysts, resulting in greener and more cost-efficient processes.

Graphical abstract: FTIR microscopy for direct observation of conformational changes on immobilized ω-transaminase: effect of water activity and organic solvent on biocatalyst performance
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Magnetic separation of immobilized biocatalyst enables continuous manufacturing with a solids-forming reaction

A new application of magnetic separation suitable for micron-scale solid–solid separation is designed and demonstrated on a pilot plant scale synthesis of amoxicillin trihydrate.

Graphical abstract: Magnetic separation of immobilized biocatalyst enables continuous manufacturing with a solids-forming reaction
From the themed collection: Biocatalysis & Bioprocessing
Paper

Efficient biosynthesis of 5-aminolevulinic acid from glutamate via whole-cell biocatalyst in immobilized engineered Escherichia coli

Development of a whole-cell catalysis system for an efficient conversion of glutamate to 5-aminolevulinic acid.

Graphical abstract: Efficient biosynthesis of 5-aminolevulinic acid from glutamate via whole-cell biocatalyst in immobilized engineered Escherichia coli
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Biocatalytic asymmetric reduction of fluoroalkyl ketones to access enantiopure fluoroalkyl secondary alcohols

An efficient biocatalytic reduction of difluoromethylene group-containing ketones with commercial ketoreductase K234 was reported to access chiral difluoromethylene-containing secondary alcohols with excellent yields and high enantioselectivity.

Graphical abstract: Biocatalytic asymmetric reduction of fluoroalkyl ketones to access enantiopure fluoroalkyl secondary alcohols
From the themed collection: Biocatalysis: A cross-journal collection
Paper

A robust and efficient lipase based nanobiocatalyst for phenothiazinyl-ethanol resolution

A new robust, active and selective biocatalyst, prepared by CaL-B entrapment into polyvinyl alcohol–chitosan nanofibers, proved to be efficient for the EKR of nine racemic phenothiazinyl-ethanols, important chiral building blocks.

Graphical abstract: A robust and efficient lipase based nanobiocatalyst for phenothiazinyl-ethanol resolution
From the themed collection: Biocatalysis & Bioprocessing
Open Access Paper

Synthetic engineering of a new biocatalyst encapsulating [NiFe]-hydrogenases for enhanced hydrogen production

By incorporating [NiFe]-hydrogenases into a proteinaceous carboxysome shell, we generate a novel biocatalyst that has improved production of clean hydrogen, oxygen tolerance, and thermostability, highlighting its great potential in biotechnological applications.

Graphical abstract: Synthetic engineering of a new biocatalyst encapsulating [NiFe]-hydrogenases for enhanced hydrogen production
Paper

Modulation of the biocatalytic activity and selectivity of CeO2 nanozymes via atomic doping engineering

Mn- and Co-doped CeO2 nanozymes were developed via atomic engineering to achieve enhanced enzymatic activity and modulation of catalytic selectivity, which could protect cells from LPS- or H2O2-induced oxidative damage by scavenging free radicals.

Graphical abstract: Modulation of the biocatalytic activity and selectivity of CeO2 nanozymes via atomic doping engineering
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Paper

Bioconversion of spent coffee grounds to prebiotic mannooligosaccharides – an example of biocatalysis in biorefinery

Spent coffee grounds can be bioconverted via Man26A to prebiotic mannooligosaccharides; this is an example of biocatalysis in the biorefinery.

Graphical abstract: Bioconversion of spent coffee grounds to prebiotic mannooligosaccharides – an example of biocatalysis in biorefinery
From the themed collection: Chemistry in Biorefineries
Paper

Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene

The development of a protecting group-free, 2-step synthesis of 5-amino-2-hydroxymethyltetrahydropyran 1a from biorenewable Cyrene™ is described which renders access to BTK-inhibitor nemtabrutinib (2) more efficient and sustainable.

Graphical abstract: Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Expression of biocatalysts and their use in monomer synthesis for biodegradable polymers from acetone and CO2

One-pot β-hydroxybutyrate synthesis from CO2 and acetone in an aqueous solution with acetone carboxylase and β-hydroxybutyrate dehydrogenase extracted from Rhodobacter capsulatus SB1003 by culturing in an acetone–bicarbonate medium was developed.

Graphical abstract: Expression of biocatalysts and their use in monomer synthesis for biodegradable polymers from acetone and CO2
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Biocatalytic approach to chiral fluoroaromatic scaffolds

New insights into the general efficacy of halohydrin dehalogenase for the synthesis of fluorinated chiral building blocks using biocatalytic and computational approaches.

Graphical abstract: Biocatalytic approach to chiral fluoroaromatic scaffolds
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Towards understanding oxygen heterocycle-forming biocatalysts: a selectivity study of the pyran synthase PedPS7

The specificity profile of the intramolecular oxa-Michael addition (IMOMA)-catalysing cyclase PedPS7 is presented. It uncovers broad substrate tolerance and high stereoselectivity of the enzyme and suggests principle differences between various subtypes of IMOMA cyclases.

Graphical abstract: Towards understanding oxygen heterocycle-forming biocatalysts: a selectivity study of the pyran synthase PedPS7
From the themed collection: Biocatalysis: A cross-journal collection
Paper

The versatility of non-heme diiron monooxygenase PmlABCDEF: a single biocatalyst for a plethora of oxygenation reactions

Whole cells of Pseudomonas putida KT2440 producing multicomponent non-heme diiron monooxygenase PmlABCDEF transforms a vast variety of compounds into different oxy-derivatives, in certain cases with high regio- or enantioselectivity.

Graphical abstract: The versatility of non-heme diiron monooxygenase PmlABCDEF: a single biocatalyst for a plethora of oxygenation reactions
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Insights into the molecular mechanism of a new efficient whole-cell biocatalyst Enterobacter ludwigii YYP3 in 5-hydroxymethylfurfural reduction

A new whole-cell biocatalyst E. ludwigii YYP3 was applied in the conversion of HMF to BHMF and exhibited outstanding catalytic efficiency and cycling stability. Its underlying molecular mechanism, especially the target enzymes responsible for HMF reduction, was revealed.

Graphical abstract: Insights into the molecular mechanism of a new efficient whole-cell biocatalyst Enterobacter ludwigii YYP3 in 5-hydroxymethylfurfural reduction
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Magnetic cross-linked enzyme aggregate based on ionic liquid modification as a novel immobilized biocatalyst for phytosterol esterification

Novel immobilized enzyme CRL-FIL-CLEAs@Fe3O4 with enhanced activities and stabilities was successfully prepared by a cross-linked lipase aggregate method for phytosterol esterification.

Graphical abstract: Magnetic cross-linked enzyme aggregate based on ionic liquid modification as a novel immobilized biocatalyst for phytosterol esterification
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Continuous oxyfunctionalizations catalyzed by unspecific peroxygenase

Unspecific peroxygenase (UPO) has been shown to be a promising biocatalyst for oxyfunctionalization of a broad range of substrates with hydrogen peroxide (H2O2) as the cosubstrate.

Graphical abstract: Continuous oxyfunctionalizations catalyzed by unspecific peroxygenase
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis

Surfactant-enabled asymmetric ATA-catalyzed reductive aminations in aqueous buffered media are described, representative of the enhanced levels of conversion made possible by the presence of a nonionic surfactant in the water, thereby enabling 1-pot chemoenzymatic catalysis.

Graphical abstract: Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Paper

Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/TEMPO)-alcohol dehydrogenase system

This article reports on a novel biocatalytic method for the synthesis of both enantiomers of lisofylline based on Trametes versicolor laccase, TEMPO as a redox mediator and stereocomplementary recombinant alcohol dehydrogenases as biocatalysts.

Graphical abstract: Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/TEMPO)-alcohol dehydrogenase system
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Rational design of a graphitic carbon nitride catalytic–biocatalytic system as a photocatalytic platform for solar fine chemical production from CO2

We report that generating (formic acid) and regenerating (NADH/NADPH) from CO2 and NAD+/NADP+ using a nitrogen-rich polymeric carbon nitride catalytic–biocatalytic system under solar light (λ > 420 nm) could provide a new approach for storage of clean energy.

Graphical abstract: Rational design of a graphitic carbon nitride catalytic–biocatalytic system as a photocatalytic platform for solar fine chemical production from CO2
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Heparosan oligosaccharide synthesis using engineered single-function glycosyltransferases

A 24-fold increase in GlcNAc-transferase ability through KfiA screening and engineering. An approach for heparosan oligosaccharide synthesis relying on single-function glycosyltransferases.

Graphical abstract: Heparosan oligosaccharide synthesis using engineered single-function glycosyltransferases
From the themed collection: Biocatalysis: A cross-journal collection
Paper

Enhancement of thermal stability of proteinase K by biocompatible cholinium-based ionic liquids

The anions of cholinium-based IL molecules interact with the protein through hydrogen bonding and other interactions, causing great influence on the thermal stability and enzymatic activity of proteinase K.

Graphical abstract: Enhancement of thermal stability of proteinase K by biocompatible cholinium-based ionic liquids
From the themed collection: Biocatalysis: A cross-journal collection
Open Access Paper

Data-rich process development of immobilized biocatalysts in flow

The authors describe an automated, data-rich screening and process development method for rapid discovery, development, and optimization of immobilized enzymes, critical to many biocatalytic processes.

Graphical abstract: Data-rich process development of immobilized biocatalysts in flow
From the themed collection: Biocatalysis & Bioprocessing
Paper

A facile approach for hierarchical architectures of an enzyme–metal–organic framework biocatalyst with high activity and stability

Enzyme-incorporated composites with hierarchical porous structures can lead to improved performance of hybrid biocatalysts.

Graphical abstract: A facile approach for hierarchical architectures of an enzyme–metal–organic framework biocatalyst with high activity and stability
From the themed collection: Biocatalysis: A cross-journal collection
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About this collection

Reducing the environmental impact of chemical synthesis while preserving the essential properties of the products to be synthesized is a key driver of innovation in the chemical sciences. Biocatalysis has become a mature technology that can complement existing catalytic approaches to improve the sustainability of chemical synthesis. By harnessing the catalytic activity and intrinsic selectivity of enzymes, a variety of molecules can be obtained, ranging from small building blocks to highly functionalized compounds, all under mild reaction conditions.

To establish biocatalysis as a key methodology in synthesis, researchers are investigating the chemical properties (stereoselectivity, substrate acceptance, and catalytic performance), physical properties (stability), and compatibility of enzymes with other synthetic steps and process conditions.


Research in these areas has led to significant advances in protein engineering, cascade design, and process engineering, while recent breakthroughs in artificial intelligence have made in silico prediction of protein structures accessible to everyone.

This cross-RSC collection brings together work from across biocatalysis research, highlighting recent advances and future prospects for this growing area.


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