A straightforward, catalyst- and additive-free method for synthesizing α-oxycarbonyl-β-ketone derivatives from β-ketosulfoxonium ylides and carboxylic acids has been described.
A cobalt-catalyzed three-component reaction of carboxylic acids, diazo reagents and tert-butyl hydroperoxide was realized, which afforded a straightforward synthesis of α-acyloxy esters in good yields.
A novel additive-free method synthesizes 2,4-disubstituted oxazoles via thiourea-mediated cyclization of α-acyloxy ketones, using accessible substrates under mild, simple conditions.
A novel substitution reaction of dichloromethane with thiols is developed, affording varieties of dithioacetals and α-acyloxy sulfides in up to 96% yields. Moreover, the obtained sulfides exhibit excellent antifungal activity against L. theobromae.
New derivatives were synthesized by the acylation of α-amino-benzylphosphonates, and by reacting them in a second Kabachnik–Fields condensation.