Issue 17, 2017

One-step formation of dihydrofuranoindoline cores promoted by a hypervalent iodine reagent

Abstract

Treatment of various substituted anilines containing a sulfonyl group in the presence of a hypervalent iodine reagent, a perfluorinated alcohol and furan promotes a formal dearomatizing [2 + 3] cycloaddition process, leading to a dihydrofuranoindoline core in useful yields. Thereafter, these functionalized systems can be used for further transformations, yielding potential key intermediates for the total synthesis of complex natural products.

Graphical abstract: One-step formation of dihydrofuranoindoline cores promoted by a hypervalent iodine reagent

Supplementary files

Article information

Article type
Paper
Submitted
10 2 2017
Accepted
05 4 2017
First published
05 4 2017

Org. Biomol. Chem., 2017,15, 3736-3741

One-step formation of dihydrofuranoindoline cores promoted by a hypervalent iodine reagent

E. Deruer and S. Canesi, Org. Biomol. Chem., 2017, 15, 3736 DOI: 10.1039/C7OB00326A

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