Issue 17, 2017
From the journal:

Organic & Biomolecular Chemistry

A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles†‡

S. R. K. Battula,ab   V. P. Rama Kishore Putta,a   G. V. Subbareddy,c   I. E. Chakravarthyd  and  V. Saravanan ORCID logo *a  

* Corresponding authors

a Medicinal Chemistry, Jubilant Biosys Ltd, 96, Industrial suburb, 2nd stage, Yeshwanthpur, Bangalore, India
E-mail: v_saravanan@jubilantbiosys.com

b Department of Chemistry, Jawaharlal Nehru Technological University, Ananthapur, Andhra Pradesh, India

c Department of Chemistry, Jawaharlal Nehru Technological University Ananthapur College of Engineering Pulivendula, 516390, YSR Dist, Kadapa, Andhra Pradesh, India

d Department of Chemistry, Rayalaseema University, Kurnool 518002, Andhra Pradesh, India

Abstract

A divergent and metal free approach has been successfully developed for the synthesis of sulfoximine tethered heterocycles. A key α-bromoalkanone intermediate 3b has been reported for the first time. Various sulfoximine tethered imidazoles, imidazopyridines, thiozoloimidazoles, imidazobenzothiazines, thiazoles and selenazoles are made from this common sulfoximine building block.

Graphical abstract: A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles

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Article information

DOI
https://doi.org/10.1039/C7OB00601B
Article type
Paper
Submitted
10 Mar 2017
Accepted
06 Apr 2017
First published
06 Apr 2017

Org. Biomol. Chem., 2017,15, 3742-3755

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A divergent and metal free synthesis of sulfoximine tethered imidazoles, imidazopyridines, imidazothiazoles, imidazobenzothiazines, thiazoles and selenazoles

S. R. K. Battula, V. P. Rama Kishore Putta, G. V. Subbareddy, I. E. Chakravarthy and V. Saravanan, Org. Biomol. Chem., 2017, 15, 3742 DOI: 10.1039/C7OB00601B

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