Issue 22, 2014

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

Abstract

Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity pattern and extended reaction scope has been achieved by transferring a reaction from batch mode to flow. This new reactivity can be explained by suppressing back mixing and precise control of temperature in a flow reactor set up.

Graphical abstract: Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

Supplementary files

Article information

Article type
Paper
Submitted
28 3 2014
Accepted
17 4 2014
First published
17 4 2014

Org. Biomol. Chem., 2014,12, 3611-3615

Author version available

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

J. Hartwig, J. B. Metternich, N. Nikbin, A. Kirschning and S. V. Ley, Org. Biomol. Chem., 2014, 12, 3611 DOI: 10.1039/C4OB00662C

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