Issue 36, 2024

A small-molecule Fenton reagent for self-augmented chemodynamic therapy by intelligently regulating intracellular acidosis

Abstract

A small-molecule Fenton reagent, integrating ferrocene with a carbonic anhydrase inhibitor, was designed to intelligently regulate intracellular acidosis for self-augmented chemodynamic therapy. Acidosis coupled with up-regulated ROS levels demonstrated potent cytotoxicity and effective tumor suppression.

Graphical abstract: A small-molecule Fenton reagent for self-augmented chemodynamic therapy by intelligently regulating intracellular acidosis

Supplementary files

Article information

Article type
Communication
Submitted
16 2 2024
Accepted
02 4 2024
First published
03 4 2024

Chem. Commun., 2024,60, 4773-4776

A small-molecule Fenton reagent for self-augmented chemodynamic therapy by intelligently regulating intracellular acidosis

K. Wang, X. Liu, Y. Jia, L. Pan, M. Shi, W. Pan, N. Li and B. Tang, Chem. Commun., 2024, 60, 4773 DOI: 10.1039/D4CC00760C

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