Issue 36, 2024

Towards tailoring hydrophobic interaction with uranyl(vi) oxygen for C–H activation

Abstract

Bovine serum albumin (BSA) has a uranyl(VI) binding hotspot where uranium is tightly bound by three carboxylates. Uranyl oxygen is “soaked” into the hydrophobic core of BSA. Isopropyl hydrogen of Val is trapped near UO22+ and upon photoexcitation, C–H bond cleavage is initiated. A unique hydrophobic contact with “yl”-oxygen, as observed here, can be used to induce C–H activation.

Graphical abstract: Towards tailoring hydrophobic interaction with uranyl(vi) oxygen for C–H activation

Supplementary files

Article information

Article type
Communication
Submitted
05 Mar 2024
Accepted
25 Mar 2024
First published
25 Mar 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 4769-4772

Towards tailoring hydrophobic interaction with uranyl(VI) oxygen for C–H activation

S. Tsushima, J. Kretzschmar, H. Doi, K. Okuwaki, M. Kaneko, Y. Mochizuki and K. Takao, Chem. Commun., 2024, 60, 4769 DOI: 10.1039/D4CC01030B

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