Issue 36, 2023

VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products

Abstract

To discover new broad-spectrum antiviral nucleotide analogues from natural resources or through protein engineering, we have developed a sensitive in vivo selection assay named Viral polymerase-Inhibition Toxin-Associated Selection (VITAS). We show that the assay works with enzymes from three Kingdoms of life.

Graphical abstract: VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products

Supplementary files

Article information

Article type
Communication
Submitted
11 2 2023
Accepted
11 4 2023
First published
11 4 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 5419-5422

VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products

A. F. Alharbi, H. Kim, D. Chumroo, Y. Ji, M. Hakil and K. H. Ebrahimi, Chem. Commun., 2023, 59, 5419 DOI: 10.1039/D3CC00638G

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