Issue 36, 2023
From the journal:

Chemical Communications

A reactive oxygen species-responsive covalent organic framework for tumor combination therapy†

Wen-Yan Li,a   Jing-Lan Kan,a   Jing-Jing Wan,a   Yan-An Li, ORCID logo a   Tian Song,a   Bo Wang,a   Qun Guan, ORCID logo a   Le-Le Zhoua  and  Yu-Bin Dong ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China
E-mail: yubindong@sdnu.edu.cn

Abstract

Herein, we report the first reactive oxygen species (ROS)-responsive dithioketal-linked covalent organic framework (COF) for synergetic chemotherapy and photodynamic therapy (PDT) of cancer. The singlet oxygen (1O2)-responsive COF dissociation and DC_AC50 drug release complement and reinforce each other to allow an efficient combination of PDT and chemotherapy.

Graphical abstract: A reactive oxygen species-responsive covalent organic framework for tumor combination therapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3CC01136D
Article type
Communication
Submitted
07 Mar 2023
Accepted
12 Apr 2023
First published
12 Apr 2023

Chem. Commun., 2023,59, 5423-5426

Permissions

Request permissions

A reactive oxygen species-responsive covalent organic framework for tumor combination therapy

W. Li, J. Kan, J. Wan, Y. Li, T. Song, B. Wang, Q. Guan, L. Zhou and Y. Dong, Chem. Commun., 2023, 59, 5423 DOI: 10.1039/D3CC01136D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements