Issue 35, 2020

Towards molecular movies with X-ray photon correlation spectroscopy

Abstract

In this perspective article we highlight research opportunities and challenges in probing structural dynamics of molecular systems using X-ray Photon Correlation Spectroscopy (XPCS). The development of new X-ray sources, such as 4th generation storage rings and X-ray free-electron lasers (XFELs), provides promising new insights into molecular motion. Employing XPCS at these sources allows to capture a very broad range of timescales and lengthscales, spanning from femtoseconds to minutes and atomic scales to the mesoscale. Here, we discuss the scientific questions that can be addressed with these novel tools for two prominent examples: the dynamics of proteins in biomolecular condensates and the dynamics of supercooled water. Finally, we provide practical tips for designing and estimating feasibility of XPCS experiments as well as on detecting and mitigating radiation damage.

Graphical abstract: Towards molecular movies with X-ray photon correlation spectroscopy

Article information

Article type
Perspective
Submitted
02 7 2020
Accepted
25 8 2020
First published
27 8 2020
This article is Open Access
Creative Commons BY-NC license

Phys. Chem. Chem. Phys., 2020,22, 19443-19453

Towards molecular movies with X-ray photon correlation spectroscopy

F. Perakis and C. Gutt, Phys. Chem. Chem. Phys., 2020, 22, 19443 DOI: 10.1039/D0CP03551C

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