Issue 6, 2015

An ortho-directed C–H borylation/Suzuki coupling sequence in the formation of biphenylbenzylic amines

Abstract

A C–H borylation/Suzuki–Miyaura coupling sequence is reported using benzylic amines to direct the C–H borylation to the ortho C–H bond. Both aryl bromides and iodides were coupled to the resulting arylboronate esters. A series of biphenylbenzylic amines are reported, requiring a single purification in the two-step reaction sequence.

Graphical abstract: An ortho-directed C–H borylation/Suzuki coupling sequence in the formation of biphenylbenzylic amines

Supplementary files

Article information

Article type
Research Article
Submitted
23 12 2014
Accepted
14 2 2015
First published
17 2 2015

Org. Chem. Front., 2015,2, 661-664

An ortho-directed C–H borylation/Suzuki coupling sequence in the formation of biphenylbenzylic amines

L. V. A. Hale, D. G. Emmerson, E. F. Ling, A. J. Roering, M. A. Ringgold and T. B. Clark, Org. Chem. Front., 2015, 2, 661 DOI: 10.1039/C4QO00348A

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