Issue 7, 2014

Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Abstract

We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.

Graphical abstract: Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Supplementary files

Article information

Article type
Communication
Submitted
05 3 2014
Accepted
19 3 2014
First published
20 3 2014
This article is Open Access
Creative Commons BY license

Metallomics, 2014,6, 1216-1219

Author version available

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