Issue 24, 2003

Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia™)

Abstract

The commercially important antihyperglycemic agent Rosiglitazone 1 (Avandia™) has been prepared in high purity by a multi-step, polymer-assisted solution phase (PASP) synthesis without the need for the conventional chromatographic purification of any intermediates.

Graphical abstract: Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia™)

Supplementary files

Article information

Article type
Paper
Submitted
03 7 2003
Accepted
22 10 2003
First published
06 11 2003

Org. Biomol. Chem., 2003,1, 4392-4395

Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia™)

X. Li, C. Abell, B. H. Warrington and M. Ladlow, Org. Biomol. Chem., 2003, 1, 4392 DOI: 10.1039/B307549D

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