Issue 72, 2018

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

Abstract

A novel strategy for the production of reactive [18F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [18F]triflyl fluoride is formed instantaneously at room temperature from hydrated [18F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [18F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [18F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [18F]fluoroestradiol ([18F]FES) and O-2-[18F]fluoroethyl-L-tyrosine ([18F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol−1.

Graphical abstract: Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
20 4 2018
Accepted
01 6 2018
First published
23 8 2018
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2018,54, 10179-10182

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

A. Pees, C. Sewing, M. J. W. D. Vosjan, V. Tadino, J. D. M. Herscheid, A. D. Windhorst and D. J. Vugts, Chem. Commun., 2018, 54, 10179 DOI: 10.1039/C8CC03206H

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