Issue 6, 2010

Diastereoselective and enantioselective Mukaiyama aldol reactions of α-ketoesters using hydrogen bond catalysis

Abstract

Hydrogen bond catalyzed Mukaiyama aldol reactions of α-ketoesters proceed in high diastereo- and enantioselectivities, giving products possessing two chiral centers, of which one is a tertiary alcohol.

Graphical abstract: Diastereoselective and enantioselective Mukaiyama aldol reactions of α-ketoesters using hydrogen bond catalysis

Supplementary files

Article information

Article type
Communication
Submitted
24 9 2009
Accepted
17 12 2009
First published
11 1 2010

Chem. Commun., 2010,46, 904-906

Diastereoselective and enantioselective Mukaiyama aldol reactions of α-ketoesters using hydrogen bond catalysis

V. B. Gondi, K. Hagihara and V. H. Rawal, Chem. Commun., 2010, 46, 904 DOI: 10.1039/B919929B

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