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Abstract | Cited by

BH3 domain mimetics based on the small protein scyllatoxin (ScTx) were designed to target the anti-apoptotic protein Bcl2 in vitro. Intrinsically disordered ScTx variants were found to bind Bcl2 with nanomolar affinity, indicating that an induced fit binding mechanism is required for favorable BH3 : Bcl2 interaction.

Graphical abstract: Targeting anti-apoptotic Bcl2 proteins with scyllatoxin-based BH3 domain mimetics

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