M. Margaret Harris, Zachary Coon, Najah Alqaeisoom, Brian Swords and Justin M. Holub
Org. Biomol. Chem., 2016,14, 440-446
DOI:
10.1039/C5OB02080H,
Communication
BH3 domain mimetics based on the small protein scyllatoxin (ScTx) were designed to target the anti-apoptotic protein Bcl2 in vitro. Intrinsically disordered ScTx variants were found to bind Bcl2 with nanomolar affinity, indicating that an induced fit binding mechanism is required for favorable BH3 : Bcl2 interaction.