Themed collection Bioinspired Surfaces Engineering for Biomaterials

G. Julius Vancso, Jian Ji, Kazuhiko Ishihara, M. Cristina L. Martins and Shaoyi Jiang introduce the Journal of Materials Chemistry B themed collection on bioinspired surfaces engineering for biomaterials.

We discuss potential causes for degrafting of polymer brushes and provide an overview of the synthetic strategies that can be utilized to prevent degrafting.

The design of antimicrobial peptide-based materials for biomedical applications such as fighting infections in various organs, cancer therapy, gene delivery and detection of bacteria.

The surface patterns of gold nanoparticles, dendrimers and DNA nanostructures are explored as a model to provide new insights into nano-bio interactions.

Zwitterionic-based topological polymers and their derivatives possess diverse topological structures and have been widely used in biomedical fields.

This review offers a bird's eye view of the development and application of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers in small biodevices such as microfluidic devices, biosensors/bioprobes, artificial implants, and drug delivery systems.

Different anionic and cationic groups occurring in zwitterions, and the pH responsive groups required for self-targeting. The different steps in self-targeting are outlined in the outer circle, numbered in the order of occurrence during self-targeting.

Tannic acid-based bioinspired coating strategies for tethering functional materials or molecules on different medical substrates for resisting bacterial pathogens and fouling agents.

This review provides a first systematic summary of aggregation-induced emission (AIE) molecules for amyloid protein aggregates associated with neurodegenerative diseases.

A new three-dimensional cell culture system for articular cartilage regeneration was developed, in which concentrated polymer brush-modified cellulose nanofibers were utilized as building blocks for the self-assembly of human mesenchymal stem cells.

PMPCylated liposomes injected into mice joints show a massive increase in retention half-life compared with PEGylated liposomes (or hyaluronan, HA), making them promising candidates as boundary lubricants at articular cartilage, or as drug carriers.

DPD simulations were adopted to study the pH- and salt-responsiveness of nanopores modified by zwitterionic PCBMA brushes, in which the switching of nanopores can be modulated by the grafting density and chain length of brushes.

A novel coating with antifouling and antimicrobial dual functions was fabricated to prevent transmission and spread of infectious diseases.

Poly(ether ether ketone) (PEEK) has seen increasing use in biomedical fields as a replacement for metal implants.

The use of zwitterion-coated particulate silicone as a bulking agent for the treatment of fecal incontinence was investigated in a rat model.

A Janus membrane can not only heal the tympanic membrane perforation with its hydrophilic surface, but also possesses the anti-adhesion properties due to its hydrophobic surface.

Biocompatible, non- ionic oil-in-water (O/W) microemulsion was developed to encapsulate and deliver novel lipophilic polymers possessing photoacoustic properties.

An emulsion hydrogel composed of thyme-oil and PSBMA was prepared by enzyme-mediated polymerization, holding promise as an antibacterial wound dressing with sustained drug release.

Zwitterionic materials have shown their ability to improve the circulation time and stability of proteins.

A biomimetic coating using a tailored phosphorylcholine-containing monomer enables to suppress non-specific protein adsorption in nanofluidic channels, paving a way to explore a new anti-biofouling strategy using monomer-based materials for nanodevices.

Photoresponsive zwitterionic polymer particles that undergo photo-assembling by ultraviolet light irradiation are designed as smart nanomaterials with the bioinert surface.

Cisplatin and autophagy inhibitor verteporfin co-loaded zwitterionic supramolecular micelles were fabricated. The therapeutic efficacy of cisplatin-based chemotherapy could be enhanced by the inhibition of autophagy.

One-step electrochemical deposition of polysulfobetaine with pyrogallol creates an antifouling sensing platform for the detection of biomarkers.

A novel modification strategy for enhancing the dispersity of MWCNTs was developed using a chimeric protein MPKE, which consisted of a zwitterionic peptide unit and a mussel adhesive protein unit. The MPKE-MWCNTs could in situ load AgNPs for 4-NP reduction.

Inspired by the stomatal feature of plant leaves, a photo-responsive membrane was developed to enhance the removal of irreversible membrane fouling and to control molecule release.

Mussel-inspired antibacterial and anti-encrustation coatings on urinary stents could in situ inhibit bacterial growth and biofilm formation, and finally reduce deposition of struvite and hydroxyapatite crystals both in vitro and in vivo.

Polymer hydrogels were prepared via gently mixing a PMB–MAPBA and PVA. The hydrogels can be easily dissociated after the addition of D-sorbitol, and immobilize cells without any reduction in bioactivity.

A general decoration of erythrocyte membrane-coated nanoparticles for enhanced tumor-targeting drug delivery based on the “CP–PC” interaction of MCP-PEG-FA and erythrocyte membranes.

Hydroxy group containing methacrylamide polymers exhibited excellent permeability into the hepatocyte multicellular tumor spheroids.

Here, we developed a bioinspired degradable polyurethane membrane with Janus surface morphology and function by integrating the bioactive dopamine (DA) and the antibacterial Gemini quaternary ammonium salt (QAS).

The carbohydrate–carbohydrate interaction was demonstrated by glyco-cluster with glycopolymers and could be measured quantitatively.

Dendrimers with phenylalanine (Phe) and cyclohexanedicarboxylic acid (CHex) showed higher uptake into various cells including T cells via endocytosis. The cell association was enhanced under weak acidic conditions observed in tumor microenvironment.

Mesenchymal stem cells can be encapsulated 3-dimensionally in a spontaneously forming polymer hydrogel. Differentiation of the cells is effectively induced by close-contact co-culturing with mature cells encapsulated in different polymer hydrogels.

Tunable mucoadhesive platform that allows crosslinking of shape conforming viscous liquids to elastic adhesive hydrogels in under a minute proposed for application to diseased sites in the oral cavity.

Water-soluble C₇₀/triblock copolymer complexes can be used as carriers that release encapsulated drugs when heated and as photosensitizers for photodynamic therapy.

A natural polysaccharide-based strategy was developed for the facile and universal antimicrobial functionalization of filtration materials.

Tissue regeneration in decellularized vascular grafts was accelerated with a patterned pore structure.

Brand new PAA–SS–rGO@BIL hydrogel beads as safe and self-anticoagulant BIL absorbents in the field of hemoperfusion.

A polymer-based nanocomposite of dual enzyme function was developed to achieve joint protease and peroxidase activities.

Introducing nitric oxide (NO) to traditional drug-eluting stents alleviates incomplete endothelialization and further inhibit the stenosis caused by the proliferation of smooth muscle cells.

Alternative liposome surface coatings for PEGylation to evade the immune system, particularly the complement system, have garnered significant interest.