Issue 95, 2023

Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window

Abstract

A Zinc phthalocyanine-based (ZnPc–PA) polymeric micelle around 70 nm and with dual-modal PTT/PDT functions for non-antibiotic bacteria eradication was developed. It showed an excellent bacterial killing efficiency of 95.2% and 96.7% in vitro against Methicillin-resistant Staphylococcus aureus (MRSA) and its biofilm, respectively. Furthermore, the in vivo experiments proved its great potential for implant-associated infection (IAI).

Graphical abstract: Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window

Supplementary files

Article information

Article type
Communication
Submitted
23 ágú. 2023
Accepted
30 okt. 2023
First published
01 nóv. 2023

Chem. Commun., 2023,59, 14169-14172

Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window

Y. Du, G. Chu, R. Yu, R. Cui, Y. Wang, Y. Mai, M. Guan, F. Xu and Y. Zhou, Chem. Commun., 2023, 59, 14169 DOI: 10.1039/D3CC04082H

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