Issue 10, 2015

Enantioselective nickel-catalyzed alkylative alkyne–aldehyde cross-couplings

Abstract

An efficient asymmetric nickel-catalyzed alkylative alkyne–aldehyde cross-coupling is developed by employing a P-chiral monophosphorus ligand BI-DIME, allowing rapid access to a series of chiral tetra-substituted olefinic allylic alcohols in high yields and good to excellent ees. The three-component reactions enjoy excellent regio- and enantioselectivities, and a broad substrate scope from readily available starting materials.

Graphical abstract: Enantioselective nickel-catalyzed alkylative alkyne–aldehyde cross-couplings

Supplementary files

Article information

Article type
Research Article
Submitted
04 maí 2015
Accepted
22 júl. 2015
First published
23 júl. 2015

Org. Chem. Front., 2015,2, 1322-1325

Enantioselective nickel-catalyzed alkylative alkyne–aldehyde cross-couplings

M. Nie, W. Fu, Z. Cao and W. Tang, Org. Chem. Front., 2015, 2, 1322 DOI: 10.1039/C5QO00148J

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