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Issue 10, 2015
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Synthesis of Passerini adducts from aldehydes and isocyanides under the auxiliary of water

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Abstract

An efficient protocol for the synthesis of the Passerini adducts α-acyloxycarboxamides from aldehydes, isocyanides and water in a molecular ratio of 3 : 1 : 3 was described. The possible mechanism for the reaction was discussed by employing cross condensation and H218O isotope labeling experiments. This method offers a straightforward access to α-acyloxycarboxamides bearing two identical functional groups in high yields under mild conditions.

Graphical abstract: Synthesis of Passerini adducts from aldehydes and isocyanides under the auxiliary of water

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Supplementary files

Article information


Submitted
25 Jun 2015
Accepted
21 Jul 2015
First published
23 Jul 2015

Org. Chem. Front., 2015,2, 1326-1333
Article type
Research Article
Author version available

Synthesis of Passerini adducts from aldehydes and isocyanides under the auxiliary of water

M. Li, B. Qiu, X. Kong and L. Wen, Org. Chem. Front., 2015, 2, 1326
DOI: 10.1039/C5QO00202H

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