Issue 3, 2021

Photo-driven self-powered biosensors for ultrasensitive microRNA detection based on metal–organic framework-controlled release behavior

Abstract

We developed a “signal-on” self-powered biosensing strategy by taking full advantage of both photoelectrochemical biofuel cells (PBFCs) and metal–organic framework (MOF)-controlled release behavior for ultrasensitive microRNA assay. PBFC-based self-powered sensors have the unique characteristics of non-requirement of external power sources, simple fabrication process, miniature size, good anti-interference ability and low cost. Furthermore, based on the target microRNA-induced release of the electron donor ascorbic acid and the high catalytic ability of the biocathode to catalyse the oxygen reduction reaction, photo-driven self-powered biosensors for ultrasensitive microRNA detection were successfully realized. The as-proposed signal-on biosensor not only provides a simple and effective strategy, but also possesses the merits of a wide dynamic concentration response range and high sensitivity for microRNA detection, with a limit of detection down to 0.16 fM.

Graphical abstract: Photo-driven self-powered biosensors for ultrasensitive microRNA detection based on metal–organic framework-controlled release behavior

Supplementary files

Article information

Article type
Communication
Submitted
19 Նյմ 2020
Accepted
10 Դկտ 2020
First published
10 Դկտ 2020

Analyst, 2021,146, 816-819

Photo-driven self-powered biosensors for ultrasensitive microRNA detection based on metal–organic framework-controlled release behavior

Y. Yu, X. Xu, Q. Su, T. Fu, W. Liu and G. Chen, Analyst, 2021, 146, 816 DOI: 10.1039/D0AN02250K

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