Issue 8, 2022

Co-Catalyzed C(sp3)–C(sp2) bond cleavage via hydrogen atom transfer

Abstract

The discovery of a new Co-catalyzed hydrogen atom transfer (HAT) C(sp3)–C(sp2) bond cleavage method to access ketones from alkenes is reported. This unprecedented transformation features mild reaction conditions and good functional group compatibility, and it proceeds through a key alkoxy radical formation and subsequent β-fragmentation approach.

Graphical abstract: Co-Catalyzed C(sp3)–C(sp2) bond cleavage via hydrogen atom transfer

Supplementary files

Article information

Article type
Research Article
Submitted
24 जनवरी 2022
Accepted
05 मार्च 2022
First published
08 मार्च 2022

Org. Chem. Front., 2022,9, 2135-2140

Co-Catalyzed C(sp3)–C(sp2) bond cleavage via hydrogen atom transfer

B. Zhou, D. Tian, J. An, Y. Zhou, R. Yan, H. Song, X. Liu and Y. Qin, Org. Chem. Front., 2022, 9, 2135 DOI: 10.1039/D2QO00125J

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