Issue 48, 2021

Releasable antimicrobial polymer-silk coatings for combating multidrug-resistant bacteria

Abstract

The development of new and effective wound dressing materials is still in demand especially considering the growing incidence of infections caused by multidrug-resistant (MDR) bacteria. In this study, we report the facile fabrication of robust silk films with embedded synthetic cationic antimicrobial polymers that can be released to combat planktonic bacteria and inhibit biofilm formation on the substrate surface. The coatings can be primed on glass or cotton substrates. The release profile of the antimicrobial polymer is tunable based on the polymer concentration, silk to polymer ratio, and film configuration. Exposure of the antimicrobial polymer-silk coating to planktonic bacteria (ca. 108 colony forming units (CFU) mL−1) over 6.5 h (and up to 24 h) yielded 5 to 7 log10 reduction in bacterial viability and ca. 7 log10 inhibition of biofilm formation against Pseudomonas aeruginosa, including a MDR strain. Against a methicillin and MDR Staphylococcus aureus strain, ca. 5 log10 reduction in bacterial viability and 3 log10 reduction in the biofilm growth were achieved. The efficacy and the simplicity of the coating methodology thus suggest that the antimicrobial polymer-silk films can potentially be applied as wound dressing materials as well as coatings for biomedical implants to combat bacterial infections.

Graphical abstract: Releasable antimicrobial polymer-silk coatings for combating multidrug-resistant bacteria

Supplementary files

Article information

Article type
Paper
Submitted
10 सितम्बर 2021
Accepted
23 नवम्बर 2021
First published
29 नवम्बर 2021

Polym. Chem., 2021,12, 7038-7047

Releasable antimicrobial polymer-silk coatings for combating multidrug-resistant bacteria

E. Wulandari, R. Budhisatria, A. H. Soeriyadi, M. Willcox, C. Boyer and E. H. H. Wong, Polym. Chem., 2021, 12, 7038 DOI: 10.1039/D1PY01219C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements