Issue 25, 2015

Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics

Abstract

Zerumbone is a phytochemical with diverse biological activities ranging from anti-inflammatory to anti-cancer properties; however, to date the cellular targets of this important compound have remained elusive. Here we report the global protein target spectrum of zerumbone in living cancer cells using competitive activity-based protein profiling of a novel cell-permeable clickable probe, combined with quantitative mass spectrometry.

Graphical abstract: Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics

Supplementary files

Article information

Article type
Communication
Submitted
29 नवम्बर 2014
Accepted
09 जनवरी 2015
First published
09 जनवरी 2015

Chem. Commun., 2015,51, 5497-5500

Author version available

Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics

K. A. Kalesh, J. A. Clulow and E. W. Tate, Chem. Commun., 2015, 51, 5497 DOI: 10.1039/C4CC09527H

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