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Issue 25, 2015
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Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(II) complex that can be photolyzed by visible light

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Abstract

We report a light-sensitive histidine building block for Fmoc/tBu solid-phase peptide synthesis in which the imidazole side chain is coordinated to a ruthenium complex. We have applied this building block for the synthesis of caged-histidine peptides that can be readily deprotected by irradiation with visible light, and demonstrated the application of this approach for the photocontrol of the activity of Ni(II)-dependent peptide nucleases.

Graphical abstract: Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(ii) complex that can be photolyzed by visible light

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Publication details

The article was received on 11 Oct 2014, accepted on 08 Jan 2015 and first published on 08 Jan 2015


Article type: Communication
DOI: 10.1039/C4CC08049A
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Citation: Chem. Commun., 2015,51, 5501-5504

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    Synthetic peptides caged on histidine residues with a bisbipyridyl ruthenium(II) complex that can be photolyzed by visible light

    J. Mosquera, M. I. Sánchez, J. L. Mascareñas and M. Eugenio Vázquez, Chem. Commun., 2015, 51, 5501
    DOI: 10.1039/C4CC08049A

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