Issue 2, 2016

Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

Abstract

Copper-catalyzed aminotrifluoromethylation of alkenes using amides as nucleophiles has been developed. It provides a rapid and efficient access to a variety of CF3-containing lactams. The reaction proceeds under mild conditions with a good scope and functional group tolerance, offering a valuable method to prepare CF3-containing lactams that are of great potential in pharmaceuticals and agrochemicals.

Graphical abstract: Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

Supplementary files

Article information

Article type
Research Article
Submitted
05 נוב 2015
Accepted
05 דצמ 2015
First published
10 דצמ 2015

Org. Chem. Front., 2016,3, 222-226

Author version available

Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

K. Shen and Q. Wang, Org. Chem. Front., 2016, 3, 222 DOI: 10.1039/C5QO00353A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements