Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Yibo Zhao; Longming Chen; Junyi Chen; Jian Li; Qingbin Meng; Andrew C.-H. Sue; Chunju Li

doi:10.1039/D3CC01405C

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers†

Yibo Zhao,^a Longming Chen,^b Junyi Chen,^bc Jian Li,

^d Qingbin Meng,

*^b Andrew C.-H. Sue

*^a and Chunju Li

*^c

Author affiliations

* Corresponding authors

^a School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300387, P. R. China
E-mail: andrewsue@xmu.edu.cn

^b State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China
E-mail: nankaimqb@sina.com

^c Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China
E-mail: cjli@shu.edu.cn

^d School of Chemistry and Chemical Engineering, Henan Normal University, P. R. China

Abstract

Herein we report the design and synthesis of a terphen[n]arene derivative functionalised with sulfate acid ester groups. This water-soluble terphen[3]arene host effectively encapsulates a multitude of neuromuscular blocking agents (NMBAs) with high affinity, showing great potential as a NMBAs reversal agent in pharmaceutical research.

This article is part of the themed collection: 2023 Pioneering Investigators

Download options Please wait...

Supplementary files

Supplementary information PDF (1893K)

Article information

DOI: https://doi.org/10.1039/D3CC01405C
Article type: Communication
Submitted: 22 מרץ 2023
Accepted: 14 אפר 2023
First published: 21 אפר 2023

Download Citation

Chem. Commun., 2023,59, 5858-5861

Permissions

Request permissions

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Y. Zhao, L. Chen, J. Chen, J. Li, Q. Meng, A. C.-H. Sue and C. Li, Chem. Commun., 2023, 59, 5858 DOI: 10.1039/D3CC01405C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Social activity

Search articles by author

Spotlight

Advertisements