Issue 30, 2020

Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation

Abstract

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are transmembrane proteins of the immunoglobulin (Ig) superfamily predominantly expressed on the cells of our immune system. Siglecs recognize sialic acid via their terminal V-set domain. In mammals, sialic acid-terminated glycolipids and glycoproteins are the ligands of Siglecs, and the monomeric affinity of Siglecs for their sialic acid-containing ligands is weak. Significant efforts have been devoted toward the development of chemically modified sialoside ligands to target Siglecs with higher affinity and selectivity. In this review we discuss natural and synthetic sialoside ligands for each human Siglec, emphasizing the ligand binding determinants uncovered from recent advances in protein structural information. Potential therapeutic applications of these ligands are also discussed.

Graphical abstract: Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation

Article information

Article type
Review Article
Submitted
30 מאי 2020
Accepted
09 יול 2020
First published
09 יול 2020

Org. Biomol. Chem., 2020,18, 5784-5797

Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation

L. D. Movsisyan and M. S. Macauley, Org. Biomol. Chem., 2020, 18, 5784 DOI: 10.1039/D0OB01116A

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