N-alkylation of indole via ring-closing metathesis/isomerization/Mannich cascade under ruthenium/chiral phosphoric acid sequential catalysis†
Abstract
A sequential catalysis by combining the Zhan-1B catalyst with chiral phosphoric acid has been utilized for N-alkylation of indole through a ring-closing metathesis/double bond isomerization/Mannich reaction cascade. Enantioenriched γ-lactams were synthesized in up to 92% yield and 95% ee.
- This article is part of the themed collection: Celebrating 70 Years of Shanghai Institute of Organic Chemistry
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