Issue 20, 2015

Resolving powers of >7900 using linked scans: how well does resolving power describe the separation capability of differential ion mobility spectrometry

Abstract

Differential ion mobility spectrometry (DIMS) separations are described using similar terminology to liquid chromatography, capillary electrophoresis, and drift tube ion mobility spectrometry. The characterization and comparison of all these separations are typically explained in terms of resolving power, resolution, and/or peak capacity. A major difference between these separations is that DIMS separations are in space whereas the others are separations in time. However, whereas separations in time can, in theory, be extended infinitely, separations in space, such as DIMS separations, are constrained by the physical dimensions of the device. One method to increase resolving power of DIMS separations is to use helium in the DIMS carrier gas. However, ions have a greater mobility in helium which causes more ions to be neutralized due to collisions with the DIMS electrodes or electrode housing, i.e. the space constraints. This neutralization of ions can lead to the loss of an entire peak, or peaks, from a DIMS scan. To take advantage of the benefits of helium use while reducing ion losses, linked scans were developed. During a linked scan the amount of helium present in the DIMS carrier gas is decreased as the compensation field is increased. A comparison of linked scans to compensation field scans with constant helium is presented herein. Resolving powers >7900 are obtained with linked scans. However, this result highlights the limitation of using resolving power as a metric to describe DIMS separations.

Graphical abstract: Resolving powers of >7900 using linked scans: how well does resolving power describe the separation capability of differential ion mobility spectrometry

Article information

Article type
Paper
Submitted
28 אפר 2015
Accepted
24 אוג 2015
First published
24 אוג 2015

Analyst, 2015,140, 6871-6878

Author version available

Resolving powers of >7900 using linked scans: how well does resolving power describe the separation capability of differential ion mobility spectrometry

B. G. Santiago, R. A. Harris, S. L. Isenberg and G. L. Glish, Analyst, 2015, 140, 6871 DOI: 10.1039/C5AN00845J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements