Themed collection Most downloaded articles of 2017: Organic Chemistry

We report a unified photoredox-catalysis strategy for both hydroxylation and amidation of tertiary and benzylic C–H bonds.

We report the first general palladium-catalyzed Suzuki–Miyaura cross-coupling of both common amides and aryl esters through the selective cleavage of the C–N and C–O bonds at ambient temperature.

Pyridine sulfinates are stable and straightforward to prepare nucleophilic coupling partners for palladium catalyzed cross-coupling reactions with aryl and heteroaryl halides. The scope with respect to the halides coupling partner is considerable, and allows the preparation of a broad range of linked pyridines.

A photoredox-catalyzed C–H functionalization of heteroarenes using a variety of primary, secondary, and tertiary alkyltrifluoroborates is reported.

Herein we present the first example of aryl radical formation via the visible light-mediated decarboxylation of aryl carboxylic acids using photoredox catalysis.

A sulfonylative variant of a “classic” cross-coupling, with a broad substrate scope. The electrophilic trapping of a sulfinate intermediate was also possible.

A catalytic redox system for the direct conjugate addition of pyridines and diazines to Michael acceptors has been developed.

Conversion of carboxylic acids to nitriles using photoredox catalysis and benziodoxolone reagents: divergent mechanism when compared to alkynylation!

A mild, efficient synthesis of sulfonyl fluorides from aryl and heteroaryl bromides utilizing palladium catalysis is described.

The use of a weakly coordinating monodentate directing group for copper-mediated ortho-hydroxylation and amination reactions allows for the identification of an external oxazoline ligand as a promoter.