Themed collection Targeted biomedical applications of nanomaterials

This article presents MXenes' potential in 3D bioprinting, discussing their benefits for bio-printed scaffolds, 3D bioprinting techniques, bio-ink criteria, applications of MXene-incorporated constructs, current challenges, and future directions.

After the discovery of DNA during the mid-20^th century, a multitude of novel methodologies have surfaced which exploit DNA for its various properties.

Enhancing cell-material interactions through surface engineering to create biomimetic environments and extend implant life.

A comprehensive overview of bioactive glass–polymer nanocomposites highlighting the various fabrication strategies, the materials involved and the major biomedical applications.

Nanocarrier-based targeting tumor-associated macrophages can reprogram pro-tumor M2 macrophages into anti-tumor M1 macrophages, offering a promising approach for advanced breast cancer treatment. Image created in BioRender.com.

This review critically examines the recent advances in the innovative use of biopolymeric and lipid-based nanomaterials in developing safer and more effective mosquito-repellent formulations to prevent mosquito-transmitted diseases.

Aging leads to diseases marked by plaque formation, increased senescent cells, and compromised body organ systems. Light-responsive nanomaterials offer a promising therapeutic approach to address the various aspects of age-related pathologies.

An overview of biosensors for airborne pathogenic fungal spore detection.

Advancements in RA therapy from conventional drugs to nanomedicines based on immune cell therapy, which increases the specificity of the treatment and decreases the off-site effects, are reported. Images are created with BioRender.com.

With the advent of DNA nanotechnology, DNA-based biomaterials have emerged as a unique class of materials at the center of various biological advances.

DNA nanostructures have surfaced as intriguing entities with vast potential in biomedicine, notably in the drug delivery area.

Conventional biomaterials suffer from mechanical stresses and biochemical degradation, compromising performance and structural integrity.

This study investigated the development and evaluation of rebamipide nanocrystals (REB-NCs) a BCS class IV drug for enhancing solubility and permeability, and used as anti-ulcer medication.

Peptide functionalized-reduced graphene oxide biomaterial for wound care applications.

Highly branched poly(N-isopropyl acrylamide) additives chain end functionalised with vancomycin have been designed to agglutinate and report on targetted Gram-positive strains of bacteria (S. aureus).

The integration capitalizes on the free radical scavenging abilities of cerium-based materials, boosting the system's antioxidant capacity. This novel drug delivery preserves the tumor suppressive impact of the anticancer drugs.

The selective assembly of ubiquicidin antimicrobial peptide near a lipid monolayer was explored in this article aiming to understand the role of available lipids in a bacterial membrane.

Schematic illustration of design, administration, and mechanism of action of Pira/Sal dual-loaded FA-conjugated redox responsive [S-(PLA-b-PEG-CONH)]₂ block copolymeric nanoparticles.

Synthesis of an L-cys_rGO hydrogel and fabrication of a BSA/anti-TNF-α/L-cys_rGO hydrogel/gSPE immunosensor.

Schematic illustrating calcium peroxide (CaO₂) nanoparticles capable of supplying H₂O₂/NO upon NIR trigger, synergising with a ferroptosis inducer, RSL-3 (CPIR NPs) for photothermal ferroptosis through mitochondrial damage and lipid peroxidation.

Diabetes mellitus (DM) is a chronic metabolic condition, characterized by hyperglycaemia, oxidative imbalance, pancreatic β-cell death, and insulin insufficiency.

Membrane active peptides (MAPs) can provide novel means to trigger the release of liposome encapsulated drugs to improve the efficacy of liposomal drug delivery systems.

Ag–TiO₂ coating on various medical-grade biomaterials demonstrates their antibacterial and antibiofilm properties.

Carbon quantum dots derived from mango leaves exhibited red fluorescence.

A rGO/ZnO nanocomposite membrane had excellent filtration properties with good antifouling behaviour.

Sustained delivery of NDGA via polymeric microparticles maintains therapeutic levels in joints, reduces cartilage damage, and alleviates post-traumatic osteoarthritis (PTOA) in mice through ROS modulation and autophagy induction.

Hemin-loaded hyaluronan needle-like microparticles can protect against the UV-induced damage of dermal fibroblasts and the accompanied oxidative and nitrosative stress.

X-ray fluorescence imaging tracks liposomes with high resolution and penetration depth. The encapsulated ruthenium(II) polypyridyl dye enables dual mode imaging.

Polyunsaturated fatty acids (PUFAs) loaded onto the porous acrylate-based scaffolds significantly enhance the expression of osteogenic markers.

Antibiotic resistance continues to pose significant health challenges. Dual action soft nanoparticles provide an advantageous platform to address it.

L-Cysteine capped MoS₂ QDs are synthesized and employed for dual-channel imaging and superior Fe³⁺ ion sensing in biological systems.

Targeted and efficient gene delivery systems hold tremendous potential for the improvement of cancer therapy by enabling appropriate modification of biological processes and the strategic design of the delivery vector plays a critical role in the improved efficacy.

Self-assembly phenomena at the liquid–liquid interface measured using inverted pendant drop tensiometry, provide insights into the jamming of nanocolloids governed through structural organization at the nanoscale due to their shape anisotropy.

A supramolecular strategy for the fabrication of a PDT-active 2D nanosheet loaded with a POD-mimicking DNAzyme for the synergetic combination of PDT and CDT for targeted cancer therapy is reported.

This work reports the fabrication of nanocomposite antimicrobial films loaded with quorum sensing inhibiting compounds exhibiting maximum ~7log₁₀ reduction in bacterial cell viability highlighting the role of preparation strategy in microbial coatings.

Biodegradable porous nanomaterials have emerged as a promising avenue for tumor drug delivery owing to their capacity to encapsulate large quantities of drugs and their compatibility with biological systems.

DNA cages loaded with Dopamine as carriers for dopamine release in neuronal cells for applications in neurological disorders.

Epoxy-based 3D microelectrode arrays facilitate extracellular recordings in non-planar environments.

Nitrogen-based quantum dots (N-Ch-CQDs) serve as an efficient biosensor platform with bioimaging capabilities to combat antibiotic resistance resulting from norfloxacin residues, which pose a significant public health threat due to their incomplete metabolism and non-biodegradable nature.

PPy flower/Ni foam-based electrode has been used for the selective detection of p-NP which showed linear detection of 0.01–20 nM, LOD of 7.18 pM and high sensitivity of 5.37 μA nM⁻¹ cm⁻².

Over the past several years, a significant increase in the expanding field of biomaterial sciences has been observed due to the development of biocompatible materials based on peptide derivatives that have intrinsic therapeutic potential.

Titanium-based orthopedic implants are gaining popularity in recent years due to their excellent biocompatibility, superior corrosion resistance and lightweight properties.