Themed collection Chemistry Biology Interface Primer

In this review, we highlight, summarize, and evaluate the use of various transition metals in the chemical synthesis of peptides and proteins with emphasis on recent developments in this exciting research area.

This tutorial review provides an introduction to a wide range of methods used to quantify protein interactions, outlining their strengths, weaknesses and requirements.

This tutorial review describes enabling methods for determining biomolecular interactions in live cells through the use of in situ generated reactive intermediates.

Herein, we describe methods to identify structured regions within disease-causing RNAs and to design lead small molecules that selectively bind these structures to modulate function.

This tutorial review provides an overview of the single protein force spectroscopy field, including the main techniques and the basic tools for analysing the data obtained from the single molecule experiments.

This tutorial review covers tools, strategies, and procedures of systems metabolic engineering facilitating the development of microbial cell factories efficiently producing chemicals and materials.

This tutorial review covers recently developed technologies employed for chemical synthesis, derivatization and analysis of lipids.

Microbial and plant specialized metabolites play key roles in mediating ecological interactions between organisms. Analysis and integration of genomics and metabolomics data facilitates charting their immense chemical diversity.

Surfaces have significantly different compositions and structures from the bulk of a material. Probing the surface requires specialized techniques and this tutorial provides a brief review of techniques used to characterize the surface and interface regions of biological materials.

Local modifications, secondary structure mimetics and global restrictions are useful synthetic tools for peptidomimetic design.