Issue 65, 2022

Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

Abstract

The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative to existing strategies using more perturbing, extrinsic photo-crosslinkers. The utility of isoxazole photo-crosslinking is demonstrated in a wide range of biologically relevant experiments, including common proteomics workflows.

Graphical abstract: Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

Supplementary files

Article information

Article type
Communication
Submitted
21 avr. 2022
Accepted
11 juil. 2022
First published
26 juil. 2022

Chem. Commun., 2022,58, 9116-9119

Author version available

Harnessing the intrinsic photochemistry of isoxazoles for the development of chemoproteomic crosslinking methods

M. G. Lougee, V. V. Pagar, H. J. Kim, S. X. Pancoe, W. K. Chia, R. H. Mach, B. A. Garcia and E. J. Petersson, Chem. Commun., 2022, 58, 9116 DOI: 10.1039/D2CC02263J

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