Regulating metal–organic frameworks as stationary phases and absorbents for analytical separations

Abstract

Metal–organic frameworks (MOFs) are highly ordered framework systems composed of metal centers and organic linkers formed through coordination bonds. The diversity of metal elements and easily modified organic ligands, together with controllable synthetic approaches, gives rise to the designability of various MOF structures and topologies and the capability of MOFs to be functionalized. Their structural diversity provides MOFs with many unique properties, such as permanent porosity, flexible structures, thermostability, and high adsorption capacity, leading to great practicability in technical applications. In this review, we concentrate on the applications of MOFs in the field of gas chromatography, high-performance liquid chromatography, and the enrichment of biomolecules, based on rational arrangements in the structures and functions of MOFs. Moreover, we emphasize the importance of structural and chemical regulations for the improvement of separation efficiency.