Issue 18, 2020

Tumor microenvironment-responsive polydopamine-based core/shell nanoplatform for synergetic theranostics

Abstract

Theranostic agents that integrate diagnostic and therapeutic modalities have drawn extensive attention due to their ability to deliver real-time imaging-guided tumor treatment. Herein, a novel core–shell polydopamine (PDA)-based theranostic agent (PDA@TA–Fe) was fabricated via a two-step strategy. Upon 808 nm and 1064 nm laser irradiation, this agent exhibited high photothermal conversion efficiencies of 29% and 41%, respectively. After endocytosis into tumor cells, the TA–Fe shell of PDA@TA–Fe gradually disintegrated in the weakly acidic tumor microenvironment (TME), and released the TA as an acidity-activated reductant that could reduce Fe3+ to Fe2+. Subsequently, the generated Fe2+ reacted with H2O2 to generate toxic hydroxyl radicals (˙OH) via the Fenton reaction, which induced the apoptosis of tumor cells and achieved the chemodynamic therapy (CDT). The heat produced by photothermal therapy (PTT) accelerated the ˙OH generation to achieve a synergetic effect of CDT/PTT. In vivo tumor-xenograft imaging and therapeutic assays demonstrated obvious contrast enhancement at the tumor site in the T1/T2-weighted MR imaging and efficient tumor suppression achieved after the intravenous injection of this agent because of the enhanced permeation and retention (EPR) effect. This study offered a new strategy to design an “all-in-one” nanoplatform for T1/T2 MR imaging-guided synergistic cancer treatment of CDT/PTT.

Graphical abstract: Tumor microenvironment-responsive polydopamine-based core/shell nanoplatform for synergetic theranostics

Supplementary files

Article information

Article type
Paper
Submitted
28 janv. 2020
Accepted
30 mars 2020
First published
03 avr. 2020

J. Mater. Chem. B, 2020,8, 4056-4066

Tumor microenvironment-responsive polydopamine-based core/shell nanoplatform for synergetic theranostics

Q. Chen, X. Shan, S. Shi, C. Jiang, T. Li, S. Wei, X. Zhang, G. Sun and J. Liu, J. Mater. Chem. B, 2020, 8, 4056 DOI: 10.1039/D0TB00248H

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