Issue 16, 2020

Nanomaterial-based biosensors for DNA methyltransferase assay

Abstract

DNA methyltransferases are responsible for catalyzing the methylation of adenine/cytosine residues in specific regions of the genome, and they participate in the establishment of epigenetic modification patterns. Deregulation of DNA methyltransferase activity will disturb DNA methylation systems, leading to the occurrence of various human diseases including cancers. Moreover, DNA methyltransferases may serve as promising therapeutic targets, and DNA methyltransferase inhibitors have been used for disease treatment. Therefore, the detection of DNA methyltransferases and screening of their inhibitors are crucial for both fundamental biomedical research studies and clinical practice. Due to their excellent size-dependent optical, chemical, electronic, and mechanical features, nanomaterials have been widely used as powerful building materials to construct efficient biosensors for DNA methyltransferase assay with high sensitivity and good selectivity. In this review, we summarize the recent progress in the development of nanomaterial-based biosensors for DNA methyltransferase assay including the strategies, features and applications, and highlight the future direction and challenges in this area as well.

Graphical abstract: Nanomaterial-based biosensors for DNA methyltransferase assay

Article information

Article type
Review Article
Submitted
03 nov. 2019
Accepted
28 janv. 2020
First published
28 janv. 2020

J. Mater. Chem. B, 2020,8, 3488-3501

Nanomaterial-based biosensors for DNA methyltransferase assay

F. Ma, Q. Zhang and C. Zhang, J. Mater. Chem. B, 2020, 8, 3488 DOI: 10.1039/C9TB02458A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements