Issue 41, 2020
From the journal:

Organic & Biomolecular Chemistry

Total synthesis of thioamycolamide A via a biomimetic route†

Chengqian Pan,a   Takefumi Kuranaga*a  and  Hideaki Kakeya ORCID logo *a  

* Corresponding authors

a Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
E-mail: tkuranaga@pharm.kyoto-u.ac.jp, scseigyo-hisyo@pharm.kyoto-u.ac.jp

Abstract

Thioamycolamide A is a biosynthetically unique cytotoxic cyclic microbial lipopeptide that bears a D-configured thiazoline, a thioether bridge, a fatty acid side chain, and a reduced C-terminus. Based on the biosynthetic insights, a concise total synthesis of thioamycolamide A was accomplished.

Graphical abstract: Total synthesis of thioamycolamide A via a biomimetic route

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Article information

DOI
https://doi.org/10.1039/D0OB01942A
Article type
Communication
Submitted
22 sept. 2020
Accepted
05 oct. 2020
First published
08 oct. 2020

Org. Biomol. Chem., 2020,18, 8366-8370

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Total synthesis of thioamycolamide A via a biomimetic route

C. Pan, T. Kuranaga and H. Kakeya, Org. Biomol. Chem., 2020, 18, 8366 DOI: 10.1039/D0OB01942A

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