Issue 22, 2019

Recent progress in photochemical radical di- and mono-fluoromethylation

Abstract

Recently, photoinduced radical difluoromethylation has emerged as a step-economical synthetic method of CHF2-containing compounds. In this article, difluoromethylation of alkenes, isonitriles and aryl bromides promoted by photoredox catalysis is described together with a non-catalytic photoinduced system. Representative reactions will be discussed for each highlighted difluoromethylating reagent. In addition, related monofluoromethylation with their corresponding monofluoromethylating reagents is also discussed.

Graphical abstract: Recent progress in photochemical radical di- and mono-fluoromethylation

Article information

Article type
Review Article
Submitted
31 mars 2019
Accepted
01 mai 2019
First published
02 mai 2019

Org. Biomol. Chem., 2019,17, 5413-5419

Recent progress in photochemical radical di- and mono-fluoromethylation

T. Koike and M. Akita, Org. Biomol. Chem., 2019, 17, 5413 DOI: 10.1039/C9OB00734B

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