Issue 17, 2018

Mannan-based conjugates as a multimodal imaging platform for lymph nodes

Abstract

We show that mannan-based conjugates possess exceptional features for multimodal imaging because of their biocompatibility, biodegradability and self-targeting properties. Two new mannan conjugates, containing a gadolinium complex and a fluorescent probe, one based only on polysaccharide and the other one comprising polysaccharide with poly(2-methyl-2-oxazoline) grafts, were prepared and simultaneously visualized in vitro and in vivo by magnetic resonance and fluorescence imaging. The synthesis of these mannan-based complexes was based on alkylation with allyl bromide or grafting with poly(2-methyl-2-oxazoline) chains, followed by a thiol–ene click reaction with cysteamine to introduce primary amino groups into their structure. Finally, the obtained conjugates were functionalized with contrast labels using the corresponding N-hydroxysuccinimide esters. When used to detect lymph nodes, the polymers showed better imaging properties than a commercially available contrast agent.

Graphical abstract: Mannan-based conjugates as a multimodal imaging platform for lymph nodes

Supplementary files

Article information

Article type
Paper
Submitted
06 nov. 2017
Accepted
03 janv. 2018
First published
03 janv. 2018

J. Mater. Chem. B, 2018,6, 2584-2596

Mannan-based conjugates as a multimodal imaging platform for lymph nodes

M. Rabyk, A. Galisova, M. Jiratova, V. Patsula, L. Srbova, L. Loukotova, J. Parnica, D. Jirak, P. Stepanek and M. Hruby, J. Mater. Chem. B, 2018, 6, 2584 DOI: 10.1039/C7TB02888A

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