Issue 5, 2017

Modulating the catalytic activity of enzyme-like nanoparticles through their surface functionalization

Abstract

The inclusion of transition metal catalysts into nanoparticle scaffolds permits the creation of catalytic nanosystems (nanozymes) able to imitate the behaviour of natural enzymes. Here we report the fabrication of a family of nanozymes comprised of bioorthogonal ruthenium catalysts inserted in the protective monolayer of gold nanoparticles. By introducing simple modifications to the functional groups at the surface of the nanozymes, we have demonstrated control over the kinetic mechanism of our system. Cationic nanozymes with hydrophobic surface functionalities tend to replicate the classical Michaelis Menten model, while those with polar groups display substrate inhibition behaviour, a key mechanism present in 20% of natural enzymes. The structural parameters described herein can be used for creating artificial nanosystems that mimic the complexity observed in cell machinery.

Graphical abstract: Modulating the catalytic activity of enzyme-like nanoparticles through their surface functionalization

Supplementary files

Article information

Article type
Paper
Submitted
11 juil. 2017
Accepted
24 oct. 2017
First published
24 oct. 2017

Mol. Syst. Des. Eng., 2017,2, 624-628

Modulating the catalytic activity of enzyme-like nanoparticles through their surface functionalization

R. Cao-Milán, L. D. He, S. Shorkey, G. Y. Tonga, L. Wang, X. Zhang, I. Uddin, R. Das, M. Sulak and V. M. Rotello, Mol. Syst. Des. Eng., 2017, 2, 624 DOI: 10.1039/C7ME00055C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements