The non-peptide-based fluorescent probe QMC11 is capable of specifically targeting asparagine endopeptidase (AEP) and imaging cellular endogenous AEP. The motion of the probe can be restricted by AEP to activate fluorescence while keeping a low background signal.
K. Li, Y. Hou, J. Han, C. Lv, W. Liu, J. Du, W. Sun, J. Fan and X. Peng, Chem. Commun., 2024, 60, 3031 DOI: 10.1039/D3CC05419E
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