Issue 13, 2024

Super-assembled periodic mesoporous organosilica membranes with hierarchical channels for efficient glutathione sensing

Abstract

Bioinspired nanochannel-based sensors have elicited significant interest because of their excellent sensing performance, and robust mechanical and tunable chemical properties. However, the existing designs face limitations due to material constraints, which hamper broader application possibilities. Herein, a heteromembrane system composed of a periodic mesoporous organosilica (PMO) layer with three-dimensional (3D) network nanochannels is constructed for glutathione (GSH) detection. The unique hierarchical pore architecture provides a large surface area, abundant reaction sites and plentiful interconnected pathways for rapid ionic transport, contributing to efficient and sensitive detection. Moreover, the thioether groups in nanochannels can be selectively cleaved by GSH to generate hydrophilic thiol groups. Benefiting from the increased hydrophilic surface, the proposed sensor achieves efficient GSH detection with a detection limit of 1.2 μM by monitoring the transmembrane ionic current and shows good recovery ranges in fetal bovine serum sample detection. This work paves an avenue for designing and fabricating nanofluidic sensing systems for practical and biosensing applications.

Graphical abstract: Super-assembled periodic mesoporous organosilica membranes with hierarchical channels for efficient glutathione sensing

Supplementary files

Article information

Article type
Paper
Submitted
12 avr. 2024
Accepted
08 mai 2024
First published
24 mai 2024

Analyst, 2024,149, 3522-3529

Super-assembled periodic mesoporous organosilica membranes with hierarchical channels for efficient glutathione sensing

H. Zeng, S. Zhou, X. Zhang, Q. Liang, M. Yan, Y. Xu, Y. Guo, X. Hu, L. Jiang and B. Kong, Analyst, 2024, 149, 3522 DOI: 10.1039/D4AN00559G

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