Issue 20, 2023

A two-photon fluorescent probe for formaldehyde detection and regeneration in living cells

Abstract

A two-photon excited fluorescent probe CMB-1 has been rationally developed for the detection and regeneration of formaldehyde based on a novel nucleophilic addition of a secondary amine to FA and subsequential alcoholysis reactivity mechanism. It enables a specific turn-on response towards formaldehyde and facilitates the monitoring of exogenous and endogenous formaldehyde in living cells via both one- and two-photon microscopy, with minimal influence on its native homeostasis and local concentration.

Graphical abstract: A two-photon fluorescent probe for formaldehyde detection and regeneration in living cells

Supplementary files

Article information

Article type
Paper
Submitted
27 janv. 2023
Accepted
22 avr. 2023
First published
24 avr. 2023

J. Mater. Chem. B, 2023,11, 4408-4415

A two-photon fluorescent probe for formaldehyde detection and regeneration in living cells

Q. Song, Z. Liu, J. Niu, B. Zheng, J. Hao and J. Jiang, J. Mater. Chem. B, 2023, 11, 4408 DOI: 10.1039/D3TB00158J

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